Background, objective, and methods: Antiphospholipid syndrome (APS) is classically regarded as a cause of thrombosis and stroke in younger patients and is often considered a rare etiology beyond the s...

Adrenal involvement is a rare but potentially severe immunothrombotic manifestation of antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE)-spectrum disease. Because the term adrenal...

Singer-songwriter Christina Perri joined Los Angeles County supervisors Tuesday to raise awareness of antiphospholipid syndrome, an autoimmune condition that can cause blood clots and increase the ris...

Antiphospholipid syndrome (APS) is a prothrombotic autoimmune disorder associated with venous thromboembolism (VTE) and chronic thromboembolic pulmonary hypertension (CTEPH). Current guidelines recommend APS screening in CTEPH patients. The exact prevalence of APS in both CTEPH and chronic thromboem …

Neonatal antiphospholipid syndrome (APS) is an exceptionally rare but clinically significant thrombotic disorder associated with antiphospholipid antibodies (aPL) in the neonatal period. Two principal pathogenic mechanisms have been proposed: passive transplacental transfer of maternal antiphospholi …

The risk of recurrent thrombosis was highest during the first 2 years after the index thrombotic event, supporting an early vulnerable phase and underscoring the need for closer clinical surveillance and secondary prevention. Limitations of the study include its retrospective design, the lack of sta …

We identified six plasma proteins that were differentially abundant in APS patients compared with controls without APS and confirmed these associations in an independent verification cohort. Collectively, these proteins may reflect subclinical inflammation and renal involvement in APS.

Most patients with cryptogenic stroke and weakly positive aPLs received antiplatelet agents. Patients with weakly positive aPLs had a lower incidence of recurrent stroke compared with patients with strongly positive aPLs, despite less intensive antithrombotic therapy.

Guidance for antiphospholipid antibody (aPL) testing after unprovoked venous thromboembolism (VTE) is inconsistent. Real-world data on the prevalence and outcomes of antiphospholipid syndrome (APS) in...

The 2023 ACR/EULAR APS classification criteria exhibit consistently excellent specificity but reduced and phenotype-dependent sensitivity. These findings reinforce the intended role of the criteria for classification rather than clinical diagnosis and highlight important limitations in specific APS …

Antiphospholipid syndrome (APS) lacks disease-modifying targeted therapies, and its molecular heterogeneity remains poorly characterized. We employed an integrative systems pharmacology approach combining weighted gene co-expression network analysis (WGCNA), single-cell RNA sequencing, Connectivity …

Rare medical case: 40-year-old woman diagnosed with four autoimmune diseases

Study led by Swansea University says long delays, limited specialist access and referral barriers are leaving some patients worse off than those elsewhere in the UK PEOPLE in Wales with autoimmune and...

This case supports the feasibility of IVIG as a bridging immunomodulatory strategy in high-risk APS cutaneous disease where standard therapies are contraindicated by concurrent infection and thrombocy...

Eye damage remains uncommon after 15 years, but certain factors increase the risk

Antiphospholipid antibodies (aPL) are a heterogeneous group of autoantibodies that target phospholipids and phospholipid-binding proteins, and are identified clinically by anticardiolipin, anti-β2-gly...

A massive single-cell study has revealed hidden genetic differences in male and female immune systems that may shape disease risk in unexpected ways.

EULAR - The European Alliance of Associations for Rheumatology - acknowledges the role of diverse real-world data to complement knowledge from randomized controlled trials.

Low-dose aspirin may lower thrombotic risk without increasing bleeding in asymptomatic aPL carriers, even in those with <3 laboratory points. P2Y12 inhibitors demonstrated reduced efficacy and an incr...

ObjectiveWe aimed to investigate the long-term thrombotic outcomes in patients with obstetric antiphospholipid syndrome (OAPS) who initially presented without thrombosis and to identify clinical featu...

Megan Preece

Antiphospholipid syndrome is a systemic autoimmune disorder characterized by thrombotic events in the presence of antiphospholipid antibodies including lupus anticoagulant, anticardiolipin, and anti-β...

Sj&ouml;gren disease, an autoimmune disease characterized by dry mouth and dry eyes, may reduce patients&rsquo; quality of life. While CD4+ T cells are key drivers of immune-mediated tissue damage and...

The role of thrombophilia in clinical decision making regarding secondary venous thromboembolism (VTE) prevention is still uncertain. Therefore, we aimed to investigate the association between heredit...

Systemic Lupus Erythematosus (SLE), commonly known as lupus, is a complex long-term disease.

Patients with RPL and aPL who exhibit the identified risk factors should undergo subsequent follow-up after pregnancy. Further research is required to investigate the potential for thrombosis preventi...

NBTE should be considered in APS patients presenting with cardiac murmurs and embolic events. TTE is essential for diagnosis. This case underscores the importance of prompt identification and a multid...

The Congress is the premier international medical and scientific conference for experts in the fields of thrombosis, hemostasis and vascular biology. Join us July 11-15 in Washington, D.C., for this m...

Acute Lyme disease is caused by a <i>Borrelia</i> infection and typically responds to antibiotic treatment, but post-infectious chronic symptoms are common. The precise origin of these post-treatment ...

The publication of the 2023 ACR-EULAR classification criteria for antiphospholipid syndrome (APS) has shifted the understanding of APS from a “one-siz…

In patients with uncertain APS diagnosis based on clinical manifestations and/or aPL positivity, measurement of VWT by ultrasonography may serve as a useful adjunctive tool in the diagnostic process.

A first-person account from Dr. Bayo Curry-Winchell, a Black family physician and the medical director for Saint Mary’s Urgent Care Group in Reno, Nevada. Curry-Winchell nearly died after giving birth...

Patients with thrombotic antiphospholipid syndrome (APS) or subjects with persistent presence of antiphospholipid antibodies (aPLA), defined “carriers”, may develop thrombocytopenia. However, the prev...

This LA-SR-based method may serve as a useful screening tool for the evaluation of LA activity. A negative LA-SR result may help identify samples unlikely to have LA activity, while positive results s...

ACTRESS Ritz Azul has revealed that she experienced two pregnancy losses before giving birth to her daughter, Baby Zie.In a social media post, Ritz shared the c