This cohort study evaluates the association between loss of chromosome Y and the incidence of aortic aneurysm based on anatomic location.

AbstractObjectives. To explore the historical development of contemporary surgical revascularization techniques.Methods. This narrative review synthesizes historical medical literature, surgical case ...

Living donor heart valves offer superior durability for pediatric patients but trigger immune rejection. Lentiviral delivery of viral immune-evasion genes US2 and Serpin b9 into donor valve cells and...

SARS-CoV-2 coronavirus infections are associated with long term vascular dysfunction, yet the drivers remain unclear. We hypothesized that remnant Betacoronavirus antigens remain in circulation and or...

Bioprosthetic heart valves (BHVs) are widely used to treat aortic valve disease, and their demand is rising. However, BHV lifespan remains limited by degener...

Current paediatric options for pulmonary heart valve (PHV) substitutes are imperfect, requiring numerous reinterventions until maturity. Substitutes with a d...

Angiogenesis requires endothelial cell (EC) plasticity and differentiation into either invasive, migratory tip cells or proliferative stalk cells. Using a transcriptional analysis that distinguished t...

AbstractAims. Acute myocardial infarction (AMI) triggers an immune response characterized by a dynamic interplay between the bone marrow (BM) and the ische

This review summarizes the current understanding of androgen physiology, relationships between androgens and cardiovascular (CV) diseases, and novel engineering approaches to study the effect of andro...

Purpose Type B aortic dissection (TBAD) managed with optimal medical therapy (OMT) carries a 40–50% risk of progressive aneurysmal degeneration. Predicting which patients will experience significant a...

Valvular heart disease is becoming more common as populations age, and the way we treat it has changed more in the past twenty years than in the fifty before...

An abdominal aortic aneurysm (AAA) is an irreversible dilation of the terminal aorta, posing significant rupture risks. Current guidelines for surgical intervention rely on aneurysm diameter threshold...

Progressive cardiomyopathy is the leading cause of death in Duchenne muscular dystrophy (DMD). Dysregulation of calcium handling has been implicated in cardiomyopathy progression in DMD. Here we descr...

Transcatheter aortic valve replacement has transformed the management of aortic stenosis; however, leaflet thrombosis and hypoattenuated leaflet thickening remain major clinical concerns. Flow disturb...

AbstractBackground and Aims. Thoracic aortic aneurysm and dissection (TAAD) can have catastrophic health consequences. Eleven genes have strong or definiti

Acute rheumatic fever is an immune-mediated sequela of Streptococcus pyogenes (group A Streptococcus) infection, presenting with fever, arthritis, chorea, rash, and, crucially, carditis. Without effec...

AbstractAims. The etiology of coronary artery Disease (CAD) appears different for men and women, yet insights into underlying sex-specific biological mecha

AbstractAims. Mitral regurgitation (MR) pathophysiology involves increased serotonin (5-HT) receptor (HTR) expression and signaling, together with reduced

Purpose Orbital atherectomy (OA) is used to treat heavily calcified peripheral arterial lesions, aiming to improve vessel compliance and reduce the need for high-pressure angioplasty and stenting. How...

Introduction This study aimed to quantitatively investigate the role of marginal chordae of the mitral valve during static closure by analyzing the force within these chordae and its potential correla...

Lipoprotein(a) [Lp(a)] is described as a low-density lipoprotein-like particle, but recent work suggests heterogeneity, including triglyceride (TG)-rich features. We investigated whether native Lp(a) ...

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Aim Patients with chronic kidney disease (CKD) have an increased cardiovascular risk. Since neutrophils and neutrophil-borne proteins contribute to cardiovascular disease, we analyzed the neutrophil.....

Although approximately 97% of the human genome does not encode proteins, it produces a vast repertoire of regulatory RNA transcripts that play critical roles...

Despite decades of investigation, effective therapies for medial arterial calcification in chronic kidney disease remain lacking. Emerging therapeutic targets increasingly extend beyond systemic drive...

Purpose Quantitative assessment of myocardial deformation is increasingly important in clinical cardiology, yet conventional two-dimensional (2D) echocardiography and standard three-dimensional (3D) a...

Proinflammatory activation of macrophages promotes various inflammatory disorders. The molecular mechanisms underlying macrophage activation, particularly in the context of nuclear translocation of pr...

Purpose Mitral valve prolapse (MVP) can lead to heart failure, arrhythmia, and death. Current treatments for MVP are strictly surgical, while alternative therapies remain elusive due to lack of knowle...

IntroductionMacrophages and their fused counterpart, foreign body giant cells (FBGCs), have a determining influence on the long-term functionality of implant...

The physical properties and architecture of biomaterial scaffolds regulate cell morphology and function; however, evaluating these effects is often sl…

Purpose Polymeric heart valves (PHVs) offer the potential to combine the durability of mechanical valves with the favorable hemodynamics of bioprosthetic valves; however, establishing clear relationsh...

Abstract figure legend High-resolution ultrasound anatomical imaging and speckle-tracking analysis were used to compute left ventricular (LV) haemodynamic forces (HDF) in a murine model of transverse...

Scientific Reports - Gut microbiome composition differs between aortic stenosis and aortic regurgitation patients

The pericardial space is a biologically active inflammatory and cellular microenvironment with growing relevance to cardiac disease and surgical practice. Pericardial fluid contains bioactive mediator...

Cardiovascular medicine; Veterinary medicine; Feline cardiology

Cadherin-11 (CDH11) is a mechanosensitive protein capable of creating cell-cell and cell-substrate junctions governing responses to environmental stimuli. It is known to perpetuate fibroblast activati...

AbstractAims. Patients with chronic kidney disease (CKD) display a reduced survival following myocardial infarction (MI). As the underlying mechanisms rema