iiinova — where your digital self keeps evolving

Anna Fiorito @annafiorito.bsky.social · 09/06/2026

—> June 17 (13:45-14:45) and June 18 (14:45-15:45) Establishing a normative reference of central sulcus width in the adult human brain by me (#2556) Central Sulcus Profile in Amyotrophic Lateral Sclerosis by @Mahan_Shafie (#1946)

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Anna Fiorito @annafiorito.bsky.social · 09/06/2026

—> June 15 (14:45-15:45) and June 16 (13:30-14:30) Genetic Correlation of Cortical Folding Patterns in Relation to Functional Brain Networks by @Mahan_Shafie (#1094)

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Anna Fiorito @annafiorito.bsky.social · 09/06/2026

Interested in how cortical folding shapes functional brain networks, how normative modeling tracks central sulcus width changes over adulthood, or how an in-depth exploration of sulcal morphometry maps onto clinical conditions like ALS? 🧠 Come check out our posters!

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Anna Fiorito @annafiorito.bsky.social · 09/06/2026

Excited to share what our team is bringing to #OHBM2026 in Bordeaux! @UniTo

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Anna Fiorito @annafiorito.bsky.social · 11/03/2026

6/6 Check out the full article available in open access at: doi.org/10.1002/hbm....

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Anna Fiorito @annafiorito.bsky.social · 11/03/2026

5/6 Since emotions are processed by a complex network, we also investigated connectivity using gPPI. We observed increased connectivity between the right amygdala and right cuneus in siblings, which possibly reflects a compensatory mechanism.

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Anna Fiorito @annafiorito.bsky.social · 11/03/2026

4/6 Using a well-matched control condition and Bayesian fMRI analyses (Thanks @hyeminhan.bsky.social for the great tool!), we found an absence of group effects in most regions, including the amygdala. Instead, a potential endophenotypic pattern was identified in the right postcentral gyrus.

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Anna Fiorito @annafiorito.bsky.social · 11/03/2026

3/6 Most previous fMRI studies used neutral stimuli as a comparator, often showing impaired amygdala activity. However, recent findings indicate that such stimuli may not be perceived as emotionally neutral by patients with schizophrenia or their relatives.

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Anna Fiorito @annafiorito.bsky.social · 11/03/2026

2/6 Behaviorally, we observed the classic endophenotypic pattern: siblings showed intermediate performance compared to patients and controls. But what about the brain correlates?

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Anna Fiorito @annafiorito.bsky.social · 11/03/2026

1/6 I am happy to announce that our latest paper is out in Human Brain Mapping!🧠 In this work, we investigated emotion processing in patients with schizophrenia, their healthy first-degree relatives, and healthy controls. @gsescousse.bsky.social @EricFakra

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Anna Fiorito @annafiorito.bsky.social · 11/03/2026

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Anna Fiorito @annafiorito.bsky.social · 11/03/2026

4/6 Using a well-matched control condition and Bayesian fMRI analyses (Thanks @xxelloss for the great tool!), we found an absence of group effects in most regions, including the amygdala. Instead, a potential endophenotypic pattern was identified in the right postcentral gyrus.

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Anna Fiorito @annafiorito.bsky.social · 11/03/2026

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Anna Fiorito @annafiorito.bsky.social · 11/03/2026

2/6 Behaviorally, we observed the classic endophenotypic pattern: siblings showed intermediate performance compared to patients and controls. But what about the brain correlates?

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Anna Fiorito @annafiorito.bsky.social · 15/01/2024

8/8 This project, including data collection, hypotheses, and statistical analyses, was transparently pre-registered on aspredicted.org (#67610, aspredicted.org/285rn.pdf)

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Anna Fiorito @annafiorito.bsky.social · 15/01/2024

7/8 Our findings reinforce microglia's role in schizophrenia pathophysiology, providing insight into regional brain heterogeneity. It also supports the use of blood samples as potential neurobiological biomarkers, reinforcing the idea of schizophrenia as a whole-body disorder

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Anna Fiorito @annafiorito.bsky.social · 15/01/2024

6/8 Additionally, we identified differential expression of microglia genes, also expressed by peripheral macrophages, in the whole blood of individuals with SZ

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Anna Fiorito @annafiorito.bsky.social · 15/01/2024

5/8 Our findings reveal widespread transcriptional downregulation of microglia genes in 4 different brain regions (cerebellum, associative striatum, hippocampus, and parietal cortex)

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Anna Fiorito @annafiorito.bsky.social · 15/01/2024

4/8 Using 9 independent transcriptional datasets from Gene Expression Omnibus database, we examined the expression of genes from a core human microglia signature. We included 8 brain regions and 3 peripheral tissues (cumulating 267 individuals with SZ and 237 healthy controls)

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Anna Fiorito @annafiorito.bsky.social · 15/01/2024

3/8 Moreover, there is a dire need for readily accessible SZ biomarkers. In this regard, peripheral tissues are a promising method to probe the transcriptome in a minimally invasive way and allow for the identification of biomarkers of altered inflammatory processes in SZ

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Anna Fiorito @annafiorito.bsky.social · 15/01/2024

2/8 Emerging evidence involves microglia alterations in schizophrenia (SZ) pathophysiology and previous research reported abnormal expression of microglia genes. However, the regional specificity of these brain transcriptional abnormalities remains unclear

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Anna Fiorito @annafiorito.bsky.social · 15/01/2024

1/8 Our new article on molecular mapping of microglia genes in schizophrenia is now out in Translational Psychiatry! Eric Fakra, @gsescousse.bsky.social, El Chérif Ibrahim, Romain Rey www.nature.com/articles/s41...

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Anna Fiorito @annafiorito.bsky.social · 14/11/2023

C'est noté pour une prochaine soumission ;)

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