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We identify FTO as an endogenous negative regulator of PARP1 and the DNA damage response in cells beyond its role as an RNA demethylase. This project is led by Tianyi Zhu, a recent PhD graduate co-supervised with Jocelyn Widagdo.
nature.com
FTO suppresses DNA repair by inhibiting PARP1 - Nature Communications
Maintaining genomic integrity is essential for the survival of organisms. Here, the authors identify FTO as an endogenous negative regulator of PARP1 and the DNA damage response in cells beyond its ro...