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andrush05.bsky.social

@andrush05.bsky.social

Reposted by @andrush05.bsky.social

Carlos A. Sánchez León @carlosasleon.bsky.social · 13/09/2026

PREPRINT 🚨 You know that feeling when you're jamming out to your favorite song (say, La Macarena 💃) and suddenly it skips, or a completely random remix drops out of nowhere? That everyday surprise tells us something profound about how our brain works! 1/24

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andrush05.bsky.social @andrush05.bsky.social · 25/04/2025

www.biorxiv.org/content/10.1... Excited to share my postdoctoral work! We mapped how loss of FMRP alters excitatory and inhibitory neurons in Fragile X Syndrome (FXS), the leading monogenic cause of autism. Huge molecular divergence — and a new therapeutic target! 🧵

biorxiv.org

Translatome profiling reveals opposing alterations in inhibitory and excitatory neurons of Fragile X mice and identifies EPAC2 as a therapeutic target.

Symptoms of Fragile X Syndrome (FXS), the leading monogenic cause of intellectual disability and autism, are thought to arise from an excitation/inhibition (E/I) imbalance. Here, we leverage cell type...

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andrush05.bsky.social @andrush05.bsky.social · 25/04/2025

www.biorxiv.org/content/10.1...

biorxiv.org

Translatome profiling reveals opposing alterations in inhibitory and excitatory neurons of Fragile X mice and identifies EPAC2 as a therapeutic target.

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