iiinova — where your digital self keeps evolving

Dr Andrew Buchanan @andrewfrsc.bsky.social · 15/08/2025

Helps my family understands me 😂

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Dr Andrew Buchanan @andrewfrsc.bsky.social · 08/03/2025

I’m talking on this topic at an ELRIG meeting in London. Your well informed commentary is super helpful. Thanks

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Dr Andrew Buchanan @andrewfrsc.bsky.social · 13/02/2025

Concur on the over hype dmd lack of clarity. The tech can make a difference but certainly not alone

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Dr Andrew Buchanan @andrewfrsc.bsky.social · 09/02/2025

This is worth watching: Prof Simon Peyton Jones, he’s very good on the public understanding of AI/ML and how do address it in education, at the Darwin College, Cambridge Lecture Series m.youtube.com/watch?si=-e_...

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Dr Andrew Buchanan @andrewfrsc.bsky.social · 16/01/2025

6. Impact on Young Adults: Children in hospices often survive longer due to excellent care. As they transition to adulthood, they may face a societal view that expedites their death, adding stress to their well-being.

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Dr Andrew Buchanan @andrewfrsc.bsky.social · 16/01/2025

4. Ethical Juxtaposition: In hospitals, critical care and mental health departments strive to save lives, while another department facilitates assisted dying. This juxtaposition raises ethical concerns and likely many legal questions.

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Dr Andrew Buchanan @andrewfrsc.bsky.social · 16/01/2025

How large will be the money motion be and is it in the government budget?

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Dr Andrew Buchanan @andrewfrsc.bsky.social · 16/01/2025

3. Healthcare Resources: How will doctors' time be allocated to support this process? Can the government ensure funding for necessary resources? Are mental health experts, skilled in capability assessment, prepared to take on this responsibility amidst existing NHS pressures?

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Dr Andrew Buchanan @andrewfrsc.bsky.social · 16/01/2025

2. Substances Used: What compounds will be used? Will they be similar to those used on death row, How long does it take for a person to die after self-administration, what safeguards will prevent people from ordering these compounds online? Will NICE approve these but not life extending medication?

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Dr Andrew Buchanan @andrewfrsc.bsky.social · 16/01/2025

1. Medical Training: How will medical training and the Hippocratic Oath be adapted? Will the General Medical Council (GMC) engage in this process? Many Dr’s did not agree to this. Will many refuse on ethical grounds, leave or retire early? What will happen when the first dose doesn’t work?

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Dr Andrew Buchanan @andrewfrsc.bsky.social · 16/01/2025

It’s driven by the same concern and compassion for suffering people’s comfort. More detailed reasons to follow :

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Dr Andrew Buchanan @andrewfrsc.bsky.social · 11/01/2025

Cold views up in Durham UK. Love the frozen waterfall ice growth

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Dr Andrew Buchanan @andrewfrsc.bsky.social · 28/12/2024

Focus on the main p(o)int in Donegal 🇮🇪

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Dr Andrew Buchanan @andrewfrsc.bsky.social · 26/12/2024

This is super as it helps crystallise how I’ve made most progress , it’s always been through science chat with 1 other person. Thank you, never saw it this clearly before

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Dr Andrew Buchanan @andrewfrsc.bsky.social · 25/12/2024

Soo many Christmas trees at St Columb’s Catherdral, Londonderry NI

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Dr Andrew Buchanan @andrewfrsc.bsky.social · 24/12/2024

Good morning Christmas Eve. Excited to have time with NI family and reflect on JRR Tolkein’s poem Noel youtu.be/VIGj3DpSrbY

youtu.be

Noel - Tolkien's Lost Christmas Poem

YouTube video by The One Ring

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Dr Andrew Buchanan @andrewfrsc.bsky.social · 22/12/2024

Winter walking around this National Trust estate

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Dr Andrew Buchanan @andrewfrsc.bsky.social · 17/12/2024

Great paper aiming to demonstrate how we could target all 2800 cell surface proteins. Three very believable examples provided. www.biorxiv.org/content/10.1...

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Dr Andrew Buchanan @andrewfrsc.bsky.social · 12/12/2024

that’s one if the reasons I chose to invest in my children’s education through independent (not private) education

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Dr Andrew Buchanan @andrewfrsc.bsky.social · 10/12/2024

Antibody geeks t-shirt. Will print it and see how it works

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Dr Andrew Buchanan @andrewfrsc.bsky.social · 08/12/2024

The challenge now is to integrate and embed this tech with the daily work of the drug discovery and precision medicine scientists.

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Dr Andrew Buchanan @andrewfrsc.bsky.social · 08/12/2024

The competition winners optimised existing mAbs and ligands - always a good optimisation strategy. For me seeing novel proteins and peptides (from PLMs, Bindcraft & RSO), bivalent avid binders, and a focus on computational efficiency was especially exciting.

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Dr Andrew Buchanan @andrewfrsc.bsky.social · 08/12/2024

🚀 Also great to see the first Biologics protein design competition by Adaptyv Bio readout. The challenge: Who can use the AI/ML tech of their choice to make a novel EGFR binder? foundry.adaptyvbio.com/competition

foundry.adaptyvbio.com

Adaptyv Foundry

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Dr Andrew Buchanan @andrewfrsc.bsky.social · 08/12/2024

📺 The Nobel Prize in Chemistry 2024 lectures www.youtube.com/live/HnT1VWz... - 20 mins David Baker: De Novo Protein Design - 55 mins Demis Hassabis: Accelerating scientific discovery with AI - 1:25 John Jumper: Building chemical and biological intuition into protein structure prediction 🧵below

youtube.com

YouTube

Share your videos with friends, family, and the world

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Dr Andrew Buchanan @andrewfrsc.bsky.social · 05/12/2024

The limitations of AI highlights the strengths of being human in the genAI world. With the figure below I try and show how the Hebrew view of humans as the Image of God is helpful in this genAI world.

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Dr Andrew Buchanan @andrewfrsc.bsky.social · 02/12/2024

I like this from old timer Oxford emeritus Prof John Lennox “Genesis 1:1 says this happened in the past, at an indefinite time. So what does the Bible say about the age of the universe and the earth? Absolutely nothing. So why fight about it folks”

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Dr Andrew Buchanan @andrewfrsc.bsky.social · 01/12/2024

It’s #Advent the first day of #Christmas🎄✨ This daily short daily reflection www.bible.com/en/reading-p... looks great to engage more with #advent this year. Thanks LICC for this 💭❄️🎄

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Dr Andrew Buchanan @andrewfrsc.bsky.social · 01/12/2024

Darwin C 1860 On the origin of species Robinson M 2024 Reading Genesis Harari YH Sapiens A brief History of Humankind

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Dr Andrew Buchanan @andrewfrsc.bsky.social · 01/12/2024

Listen or read JH Walton on Genesis 1 it’s changed my view of what’s fundamental😉. here’s a podcast also great YouTube lectures open.spotify.com/episode/2GX4...

open.spotify.com

Genesis 1-2: Origins or Identity? – Feat. Dr. John Walton

BibleProject · Episode

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Dr Andrew Buchanan @andrewfrsc.bsky.social · 01/12/2024

Thanks for the commentary from an antibody engineer implementing and playing around with these approaches. These tools can help in optimisation mode and getting closer to hit discovery mode.

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Dr Andrew Buchanan @andrewfrsc.bsky.social · 01/12/2024

“fundamentally all of these models are AF3-derivatives trained on the same data, so it's not surprising that performance is generally very similar”

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Dr Andrew Buchanan @andrewfrsc.bsky.social · 01/12/2024

Love this insight on the AI tools Alphafold 3, Boltz and Chai-1 in antibody engineering (my day job). “It appears that these models well understand how antibodies fold, but not how they bind.” Thanks @btnaughton.bsky.social Post: blog.booleanbiotech.com/alphafold3-b...

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Dr Andrew Buchanan @andrewfrsc.bsky.social · 30/11/2024

Refs Mangalwadi V2011 The Book that made your world. Thomas Nelson Schmid K 2018 Who wrote the Torah? Princeton, New Jersey, USA Barton J 2019 A History of the Bible, The book and its faiths. Penguin, UK. Jongkind D 2023 How we got the Bible: The story of Scripture. Tyndale House, Cambridge, UK.

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Dr Andrew Buchanan @andrewfrsc.bsky.social · 30/11/2024

I’ve found the Bible surprisingly helpful in thinking about Human+ in the age of AI 🤖. Before saying why these figures give some context on approaching the ancient foreign scrolls 📜 Figures 1) our chemical, biological & human timeline 2) how we got the bible 3) degrees of historical latitude

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Dr Andrew Buchanan @andrewfrsc.bsky.social · 29/11/2024

Great write up but I can’t agree it’s a good outcome

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Dr Andrew Buchanan @andrewfrsc.bsky.social · 29/11/2024

Christmas has come to Cambridge Biomedical Campus. Love to see the tree in the green between @Astrazeneca DISC and @royalpapworth.bsky.social

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Dr Andrew Buchanan @andrewfrsc.bsky.social · 29/11/2024

I’m sorry we are at this point in the UK. The safe guards will not work and the public mislead

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Dr Andrew Buchanan @andrewfrsc.bsky.social · 24/11/2024

✅ This is a real step forward in demonstrating an integrated and digital AI enabled antibody discovery platform. 🎯 Great to see them include a novel target X as a critical challenge in R&D is choose the right target. #antibodies #biotechnology #drugdiscovery

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Dr Andrew Buchanan @andrewfrsc.bsky.social · 24/11/2024

They experimental validation for four (epitope, in vitro function, affinity and developability) of the nine attributes of a high quality antibody #CandidateDrug is impressive. Technical nabla-public.s3.us-east-1.amazonaws.com/2024_Nabla_J...

nabla-public.s3.us-east-1.amazonaws.com

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Dr Andrew Buchanan @andrewfrsc.bsky.social · 24/11/2024

The diversity of AI de novo protein design tools is baffling. I read the Nabla Bio team’s recent technical report. 🔥The combination of their #JAM (Joint Atomic Modeling) with experimental validation of the attributes required of a high quality antibody #CandidateDrug is impressive

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Dr Andrew Buchanan @andrewfrsc.bsky.social · 19/11/2024

Great few days talking all things protein science with #ELRIG in Cambridge UK

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Dr Andrew Buchanan @andrewfrsc.bsky.social · 17/11/2024

Virtual Lab, an AI-human research collaboration ❤️ biorxiv 📄 www.biorxiv.org/content/10.1... What integrated human + AI in #drugdiscovery can be: clear human defined question, strategy, and overview; ML tools as agents, not bots; well evaluated outcome Bright future for #ML, #wetlab, #proteindesig

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