iiinova — where your digital self keeps evolving

Reposted by Andrew Payne

Ed Boyden @eboyden3.bsky.social · 02/10/2025

Wonderful to collaborate with, and to support as an advisor, E11 Bio - and to announce PRISM, a technology for mapping brains in a self-correcting way, by barcoding neurons followed by expansion microscopy! Thread below by E11 Bio CEO Andrew Payne, with preprint at, www.biorxiv.org/content/10.1...

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Andrew Payne @andrewcpayne.bsky.social · 01/10/2025

In our first study, we acquired a unique dataset in mouse hippocampus. Barcodes improved the accuracy of tracing genetically labelled neurons by 8x – with a clear path to 100x or more. They also permit tracing across spatial gaps – essential for mitigating tissue section loss in whole-brain scaling.

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Andrew Payne @andrewcpayne.bsky.social · 01/10/2025

We discovered a new cell barcoding approach exceeding comparable methods by more than 750x. This is the heart of PRISM. We integrated this capability with microscopy and AI image analysis to automatically trace neurons at high resolution and annotate them with molecular features.

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Andrew Payne @andrewcpayne.bsky.social · 01/10/2025

E11 Bio is excited to unveil PRISM technology for mapping brain wiring with simple light microscopes. Today, brain mapping in humans and other mammals is bottlenecked by accurate neuron tracing. PRISM uses molecular ID codes and AI to help neurons trace themselves. Read more: e11.bio/blog/prism

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Andrew Payne @andrewcpayne.bsky.social · 01/10/2025

In our first study, we acquired a unique dataset in mouse hippocampus. Barcodes improved the accuracy of tracing genetically labelled neurons by 8x–with a clear path to 100x or more. They also permit tracing across spatial gaps–essential for mitigating tissue section loss in whole-brain scaling.

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Andrew Payne @andrewcpayne.bsky.social · 01/10/2025

PRISM uses molecular ID codes and AI to help neurons trace themselves. We discovered a new cell barcoding approach exceeding comparable methods by more than 750x. We integrated this with microscopy and AI image analysis to automatically trace neurons at high resolution with molecular features.

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Andrew Payne @andrewcpayne.bsky.social · 30/05/2025

Congrats to Arlo Sheridan and Will Patton for releasing Volara, our first open-source library for scalable image processing, and also for a great technical writeup!

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Andrew Payne @andrewcpayne.bsky.social · 05/02/2025

@e11bio.bsky.social needs help to scale optical connectomics to humans and other mammals! Huge opportunity to have an impact on brain science as part of a world-class, mission-driven team. #hiring computational scientists at all levels to build data pipelines for brain microscopy images! 🧪

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Andrew Payne @andrewcpayne.bsky.social · 03/12/2024

🧪 E11 Bio is excited to share a major step towards brain mapping at 100x lower cost, making whole-brain connectomics at human & mouse scale feasible (🧠→🔬→💻). Critical for curing brain disorders, building human-like AI systems, and even simulating human brains. Read more: e11.bio/news/roadmap

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Andrew Payne @andrewcpayne.bsky.social · 20/11/2024

Hi Monica, I'm working on a non-profit open science project for brain connectome mapping. Would love to be added to the science feed. scholar.google.com/citations?us...

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