Cyclic stretch, generated by pulsatile blood pressure, has been identified as a pivotal regulator of vascular smooth muscle cell (VSMC) behavior and arterial wall homeostasis. Research has demonstrate...

Batta et al. identified ARHGEF18 as a flow-responsive RhoGEF with high phosphorylation-dependent activity under physiological shear stress and as necessary to maintain tight junctions by recruiting ZO...

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Background: Intracranial aneurysm (IA) is a common cerebrovascular abnormality characterized by localized dilation and wall thinning in intracranial arteries, that frequently leads to fatal sub-arachn...