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Amy Brock

@amybrock.bsky.social

cells, cell ecosystems, cancer, heterogeneity, molecular & cellular technologies, professor, mom^5, gardening, books & more books, racing sailboats

Posts Replies Media

Amy Brock @amybrock.bsky.social · 05/09/2025

if I just keep stretching my arm, some kind of lamarckian mechanism is bound to kick in?

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Amy Brock @amybrock.bsky.social · 25/02/2025

So the contents of every US research grant proposal are also now likely available to “malign foreign actors”. Any universities or companies talking about this point?

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Reposted by Amy Brock

Denis Wirtz @deniswirtz.bsky.social · 14/02/2025

Today, send a note to your NIH program officers to thank them for the amazing work they have done to support your research. They have been critical in making this country a leader in life sciences. Do it now.

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Amy Brock @amybrock.bsky.social · 23/01/2025

Update: now cancelled. Just awful.

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Amy Brock @amybrock.bsky.social · 23/01/2025

I’m on NIH study section in one week & have not (yet) received any communication about cancellation. Just throwing my data point out there.

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Amy Brock @amybrock.bsky.social · 23/12/2024

Tenar of Earthsea. She gives up a ring (and much more)!

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Amy Brock @amybrock.bsky.social · 20/12/2024

This is the thesis work of Andrea Gardner, a talented recent grad of the lab. We look forward to using CMDuo to explore these ideas further & would be happy to hear your input as we move this ms towards submission!

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Amy Brock @amybrock.bsky.social · 20/12/2024

Fusion is a mechanism that results in WGD & aneuploidies, and as such may contribute to the ways that cancer avoids Muller’s ratchet.

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Amy Brock @amybrock.bsky.social · 20/12/2024

Since at least 1976 (Nowell), cancer evolution has been viewed as conceptually similar to Darwinian evolution of asexually reproducing organisms. We hypothesize that rates of proliferative fusion cells may be higher than currently appreciated in many tumor cell populations.

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Amy Brock @amybrock.bsky.social · 20/12/2024

In TNBC cells we uncovered subclonal transcriptomic hybridization and unveiled distinct cell-states which arise in cancer cell fusion. Cell-cell fusion increases population heterogeneity.

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Amy Brock @amybrock.bsky.social · 20/12/2024

ClonMapper Duo (‘CMDuo’), identifies cells that have undergone fusion by a reporter expression & reporter-associated index sequences paired to random barcode sets. scRNA-seq of the indexed barcodes enables the mapping of each set of parental cells and fusion progeny throughout a cell population.

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Amy Brock @amybrock.bsky.social · 20/12/2024

The role of cell-cell fusion in cancer has been understudied due to limited experimental systems for tracking and analyzing individual fusion events. To meet this need, we developed a molecular toolkit to map the origins and outcomes of individual cell fusion events within tumor cell populations.

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Amy Brock @amybrock.bsky.social · 20/12/2024

Cell-cell fusion is a tightly controlled process in the body, involved in fertilization, placental development, muscle growth, bone remodeling, & viral response, among others.

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Amy Brock @amybrock.bsky.social · 20/12/2024

Excited to share this preprint as a 1st post 🦋. Here we redesign our cell barcode tech to map cell-cell fusion events in cancer cells. www.biorxiv.org/content/10.1...

biorxiv.org

Mapping cell-cell fusion at single-cell resolution

Cell-cell fusion is a tightly controlled process in the human body known to be involved in fertilization, placental development, muscle growth, bone remodeling, and viral response. Fusion between canc...

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