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Gil Amitai

@amitaig.bsky.social

39 followers 25 following 0 posts

Working on the immune system of bacteria at the Sorek lab

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Reposted by Gil Amitai

Bohdana Hurieva🇺🇦 @bhurieva.bsky.social · 23/04/2026

🎉Excited to share our new preprint! TIR domains from diverse animals, including human TLR4, are catalytically active and produce cyclic ADP-ribose (cADPR). This enzymatic activity is widespread in animals and conserved across the tree of life. www.biorxiv.org/content/10.6...

biorxiv.org

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Reposted by Gil Amitai

Jeremy Garb @garbjeremy.bsky.social · 02/09/2025

📢 New preprint alert! We designed synthetic proteins that can block bacterial immune systems, allowing phages + plasmids to overcome natural defenses. This could transform phage therapy + genetic engineering. Here’s what we found 🧵 Preprint🔗: www.biorxiv.org/content/10.1...

biorxiv.org

Synthetically designed anti-defense proteins overcome barriers to bacterial transformation and phage infection

Bacterial defense systems present considerable barriers to both phage infection and plasmid transformation. These systems target mobile genetic elements, limiting the efficacy of bacteriophage-based t...

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