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Denis - The COVID Info Guy @thecovidinfoguy.bsky.social · 22/12/2025

US Weekly COVID update: Dec 22, 2025 🔸1 in 67 Actively Infectious 🔸732,000 New Daily Infections 🔸4,470,000 Infections In The Past Week 🔸232,000,000 Infections in 2025 🔸224,000 to 890,000 Weekly Long COVID Cases 🔸1,300 to 2,200 Weekly Deaths Source: pmc19.com/data/

A colour-coded map of the United States titled “COVID-19 Heat Map, Based on CDC Wastewater Data and Levels (U.S.)” dated December 22, 2025. The map is produced by the Pandemic Mitigation Collaborative (PMC) and attributed to Michael Hoerger, PhD, MSCR, MBA. States are shaded by COVID-19 wastewater transmission levels: Very High (dark red), High (red), Moderate (orange), Low (yellow), Very Low (pale yellow), and Limited Data (diagonal stripes). Several Midwest and parts of the Northeast show moderate to high levels, with at least one state in very high. A note says data were last updated 12/13/25 and that levels may be worse than shown. Text at the bottom states the U.S. is in its 12th COVID wave, with 16 states at moderate to very high transmission as of December 13, and variability even in very low regions. The website pmc19.com/data appears on the map.

Date: December 22, 2025
Author: Michael Hoerger, PhD, MSCR, MBA

A table titled “National COVID-19 Estimates (U.S.)” dated December 22, 2025, from the Pandemic Mitigation Collaborative (PMC) model with the source pmc19.com/data.

Infections:
– Proportion actively infectious: 1 in 67 (1.5%)
– New daily infections: 732,000
– Infections in the past week: 4,470,000
– Infections in 2025: 232,000,000
– Cumulative infections per person: 4.86

Long COVID:
– New daily infections leading to Long COVID: 37,000–146,000
– New weekly infections leading to Long COVID: 224,000–890,000

Excess deaths:
– From new daily infections: 220–360
– From new weekly infections: 1,300–2,200

A note at the bottom states that daily infections are about the same as last week, and that roughly 4.5 million weekly infections are expected to result in over 200,000 new chronic conditions and approximately 2,000 excess deaths.

Date: December 22, 2025
Author/Source: Pandemic Mitigation Collaborative (PMC)

A table titled “COVID-19 State Prevalence Estimates” dated December 22, 2025, from the Pandemic Mitigation Collaborative (PMC) model, source pmc19.com/data. The table lists U.S. states with columns for CDC level, estimated percentage actively infectious, and the chance that at least one person is infectious in a room of 10, 25, 50, or 100 people.

Most states are marked Very Low, Low, or Moderate, while Connecticut, Kentucky, and Maine are highlighted in red as High prevalence. Estimated active infection ranges from 1 in 392 (0.3%) in California to 1 in 30–36 (2.8–3.4%) in high-prevalence states. Room-risk estimates rise sharply in high states, reaching 94–97% for rooms of 100 people.

Several states are marked with an asterisk indicating limited data reporting. A note states that levels are likely considerably higher today due to lagged state reporting. Data last updated: 12/13/25.

Date: December 22, 2025
Author/Source: Pandemic Mitigation Collaborative (PMC)

A continuation table titled “COVID-19 State Prevalence Estimates” dated December 22, 2025, from the Pandemic Mitigation Collaborative (PMC) model, source pmc19.com/data. It lists U.S. states from Missouri through Wyoming, showing CDC level, PMC estimate of the percentage actively infectious, and the chance that at least one person is infectious in rooms of 10, 25, 50, or 100 people.

Most states are categorized as Very Low, Low, or Moderate. Oklahoma is highlighted in red as High, with an estimate of 1 in 40 (2.5%) actively infectious, and room-risk estimates rising to 92% in a 100-person room. Moderate states include Nebraska, New Hampshire, New Mexico, North Dakota, Ohio, South Dakota, and West Virginia.

Footnotes indicate limited reporting for some states, and that North Dakota has no direct data, using averages from Minnesota, Montana, and South Dakota. A note explains that Puerto Rico provides qualitative estimates only, and that actual levels are likely considerably higher today due to lagged state reporting. Data last updated: 12/13/25.

Date: December 22, 2025
Author/Source: Pandemic Mitigation Collaborative (PMC)

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