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Alfred Fischer

@alfredodistefano.bsky.social
74 followers 81 following 443 posts

I love science, studied biology and am working with cancer drugs. Twitter in German: x.com/alfredfischer17?s=21

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Alfred Fischer @alfredodistefano.bsky.social · 11/07/2026
Frecce Tricolori
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Alfred Fischer @alfredodistefano.bsky.social · 15/06/2026
The Ozempic Mouth
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Alfred Fischer @alfredodistefano.bsky.social · 15/06/2026
Research on Physical Activity and Breast Cancer Peaked in Past 5 Years www.cancertherapyadvisor.com/news/physical-activity-breast-cancer/
cancertherapyadvisor.com
Research on Physical Activity and Breast Cancer Peaked in Past 5 Years
Investigators sought to describe research trends and patterns in the scientific literature related to physical activity and breast cancer.
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Alfred Fischer @alfredodistefano.bsky.social · 13/06/2026
Baroque ceiling painting
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Alfred Fischer @alfredodistefano.bsky.social · 10/06/2026
Coronary artery calcification may be associated with cardiovascular events and mortality in patients with advanced-stage NSCLC www.resmedjournal.com/article/S095...
resmedjournal.com
Association of coronary calcification or vascular inflammation and cardiovascular events and prognosis in non-small cell lung cancer: A retrospective study
Coronary artery disease and lung cancer share common risk factors, which may increase the risk of cardiovascular events in patients with lung cancer. Coronary artery calcification (CAC) and vascular i...
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Alfred Fischer @alfredodistefano.bsky.social · 05/06/2026
2010 to 2021 Saw Increase in Incidence of Stage IV Breast Cancer www.cancertherapyadvisor.com/news/2010-to...
cancertherapyadvisor.com
2010 to 2021 Saw Increase in Incidence of Stage IV Breast Cancer
Significant increase seen across all age groups, all racial groups, both sexes
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Alfred Fischer @alfredodistefano.bsky.social · 03/06/2026
The combination of heart, kidney and metabolic diseases, known as cardiorenal-metabolic (CKM) syndrome, is also associated with an increased risk of cancer, according to a retrospective study. doi.org/10.1161/CIRC...
doi.org
Association Between Cardiovascular-Kidney-Metabolic Syndrome and Cancer Development: Insights From a Nationwide Database Study in Japan | Circulation: Population Health and Outcomes
BACKGROUND: Cardiovascular-kidney-metabolic (CKM) syndrome is a recently proposed framework emphasizing the interconnected nature of cardiovascular, kidney, and metabolic disorders. These conditions s...
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Alfred Fischer @alfredodistefano.bsky.social · 02/06/2026
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Alfred Fischer @alfredodistefano.bsky.social · 29/05/2026
Regional Blocks Reduce Opioid Use and Improve Recovery After Breast Surgery www.dovepress.com/serratus-pos...
dovepress.com
Serratus posterior superior intercostal plane block versus serratus an | JPR | Dove Medical Press
The SPSIPB and SAPB reduced opioid consumption and improved quality of recovery compared with conventional management
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Alfred Fischer @alfredodistefano.bsky.social · 29/05/2026
Pregnancy, Childbirth Do Not Affect Outcomes in Young Women with Early Breast Cancer academic.oup.com/jnci/advance...
academic.oup.com
Pregnancy history, recency of childbirth, and outcomes in young women with early-stage breast cancer
AbstractBackground. Breast cancer (bc) diagnosed during pregnancy or postpartum often presents with aggressive features, potentially influenced by hormonal
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Alfred Fischer @alfredodistefano.bsky.social · 28/04/2026
Cancer Alley is a nickname given to a stretch of land along the Mississippi River between Baton Rouge and New Orleans. This area contains over 200 petrochemical plants and refineries and accounts for 25% of the petrochemical production in the United States.
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Alfred Fischer @alfredodistefano.bsky.social · 28/04/2026
A falcon’s hovering is pure precision: with rapid wingbeats, it appears to stand still in midair while locking onto prey below. It continuously compensates for wind and motion with fine muscular control.
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Alfred Fischer @alfredodistefano.bsky.social · 27/04/2026
Ultra processed food intake was not associated with postmenopausal breast cancer academic.oup.com/jnci/advance...
academic.oup.com
Title: Ultra-processed food intake and postmenopausal breast cancer risk in the NIH-AARP diet and health study
AbstractBackground. UPF intake is associated with obesity. Despite obesity being a risk factor for postmenopausal breast cancer, evidence for an associatio
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Alfred Fischer @alfredodistefano.bsky.social · 22/04/2026
With the advent of agriculture, part of our sense of smell disappeared. This is also a way evolution works. www.cell.com/cell-reports...
cell.com
Gene-culture coevolution shapes olfactory receptor gene diversity in Orang Asli populations
Ma et al. reveal that Orang Asli hunter-gatherers retain more ancestral olfactory receptor (OR) gene variants and harbor fewer mutations than agricultural populations, consistent with their relatively...
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Alfred Fischer @alfredodistefano.bsky.social · 22/04/2026
Annual ctDNA Testing Could Detect Cancers “Substantially in Advance” of Clinical Diagnosis acsjournals.onlinelibrary.wiley.com/doi/full/10....
acsjournals.onlinelibrary.wiley.com
Early cancer detection in a large American Cancer Society cohort study: Retrospective analysis of methylated DNA biomarkers
This analysis of biobanked plasma samples from 2754 American Cancer Society Cancer Prevention Study 3 study participants informed the biology and preclinical detectability of methylated DNA signals f....
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Alfred Fischer @alfredodistefano.bsky.social · 22/04/2026
Ovarian Cancer Incidence, Mortality Elevated in High Radon Zone jamanetwork.com/journals/jam...
jamanetwork.com
Residential Radon Levels and Ovarian Cancer Among Postmenopausal Women
This cohort study uses data from the Women’s Health Initiative to evaluate whether higher residential radon levels are associated with an increased risk of ovarian cancer among postmenopausal women.
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Alfred Fischer @alfredodistefano.bsky.social · 16/04/2026
AI-powered mammography detects not only cancer but also vascular calcifications, thus identifying heart risk at an early stage. academic.oup.com/eurheartj/ad...
academic.oup.com
Artificial intelligence–based quantification of breast arterial calcifications to predict cardiovascular morbidity and mortality
AbstractBackground and Aims. Women are underdiagnosed and undertreated for cardiovascular disease (CVD). Automatic quantification of breast arterial calcif
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Alfred Fischer @alfredodistefano.bsky.social · 16/04/2026
The risk that cancer survivors will develop a subsequent primary cancer (SPC) has risen over the last 20 years, according to research published in Cancer Medicine. onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com
Rising Risk of Subsequent Primary Cancers Among US Cancer Survivors, 2000–2021
Background As cancer survival improves, the population at risk for subsequent primary cancers (SPCs) is growing rapidly. Yet, contemporary trends in SPC incidence remain undercharacterized, limiting...
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Alfred Fischer @alfredodistefano.bsky.social · 13/04/2026
Low BMI Linked to Progression in HR+/HER2– Breast Cancer Treated With CDK4/6i jnccn.org/view/journal...
jnccn.org
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Alfred Fischer @alfredodistefano.bsky.social · 13/04/2026
Better Survival, Cardiometabolic Outcomes in Breast Cancer Patients With Sufficient Vitamin D Levels #oncology jnccn.org/view/journal...
jnccn.org
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Alfred Fischer @alfredodistefano.bsky.social · 13/04/2026
Colon cancer: For older adults, a screening colonoscopy seems to be less important. doi.org/10.1001/jama...
doi.org
Colorectal Cancer and Mortality Risk Among Older Adults With vs Without Adenoma on Prior Colonoscopy
This retrospective cohort study compares cumulative colorectal cancer risk and all-cause mortality among adults 75 years of age or older with vs without adenoma at prior colonoscopy.
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Alfred Fischer @alfredodistefano.bsky.social · 13/04/2026
Strong prenatal exposure to PFAS is associated with increased asthma incidence. #pollution doi.org/10.1371/jour...
doi.org
Prenatal exposure to per- and polyfluoroalkyl substances (PFAS) and incidence of asthma and wheeze in childhood: A register-based cohort study in Ronneby, Sweden
In a cohort study, Annelise Blomberg and colleagues investigate the association between prenatal perfluoroalkyl substances exposure and childhood incidence of asthma and wheeze in a highly-exposed pop...
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Alfred Fischer @alfredodistefano.bsky.social · 13/04/2026
The ability to move a weight with force may be a better predictor of mortality risk than how much weight you can move overall. www.medscape.com/s/viewarticl...
medscape.com
The Case for Muscle Power Over Strength
The ability to move a weight with force may be a better predictor of mortality risk than how much weight you can move overall. A beneficial tweak for exercise Rx?
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Alfred Fischer @alfredodistefano.bsky.social · 09/04/2026
Patients With Acromegaly Have Higher Risk for Cancer #oncology #epidemiology academic.oup.com/jcem/advance...
academic.oup.com
Acromegaly is Associated with an Increased Incidence of Primary Malignant Tumors: Data from a National Study in Sweden
AbstractContext. Growth hormone (GH) excess and elevated insulin-like growth factor-1 (IGF-1) in acromegaly are considered to promote cancer development.Ob
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Alfred Fischer @alfredodistefano.bsky.social · 01/04/2026
Beta-blocker use was associated with improved OS and PFS in patients with solid cancers. #oncology academic.oup.com/jnci/advance...
academic.oup.com
Impact of beta-blockers on prognostic outcomes in solid cancers: a systematic review and meta-analysis
AbstractBackground. Beta-blockers are conventionally prescribed for cardiovascular indications and have potential for repurposing in oncology as adrenergic
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Alfred Fischer @alfredodistefano.bsky.social · 31/03/2026
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Alfred Fischer @alfredodistefano.bsky.social · 13/03/2026
Previously, two doctors were needed to interpret a mammogram. Now it turns out that if one doctor is replaced by AI, the assessments are more frequently correct. #breast #cancer www.thelancet.com/journals/lan...
thelancet.com
Interval cancer, sensitivity, and specificity comparing AI-supported mammography screening with standard double reading without AI in the MASAI study: a randomised, controlled, non-inferiority, single...
AI-supported mammography screening showed consistently favourable outcomes compared with standard double reading, with a non-inferior interval cancer rate, fewer interval cancers with unfavourable cha...
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Alfred Fischer @alfredodistefano.bsky.social · 13/03/2026
Complementary and Alternative Medicine Associated with Higher Mortality for Women with Breast Cancer. jamanetwork.com/journals/jam...
jamanetwork.com
Use of Complementary and Alternative Medicine in the Management of Breast Cancer
This cohort study assesses the association of complementary and alternative medicine plus traditional therapies, including surgery, chemotherapy, radiation, endocrine therapy, and immunotherapy, with ...
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Alfred Fischer @alfredodistefano.bsky.social · 11/03/2026
Calcifications in the arteries of the mammary gland, which become visible in mammography, indicate an increased risk of serious cardiovascular events. doi.org/10.1093/eurh...
doi.org
Artificial intelligence–based quantification of breast arterial calcifications to predict cardiovascular morbidity and mortality
AbstractBackground and Aims. Women are underdiagnosed and undertreated for cardiovascular disease (CVD). Automatic quantification of breast arterial calcif
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Alfred Fischer @alfredodistefano.bsky.social · 09/03/2026
Wildfire Smoke Tied to Higher Stroke Incidence, Greater Severity #air #quality www.science.org/doi/10.1126/...
science.org
Wildfire smoke PM2.5 and mortality rate in the contiguous United States: A causal modeling study
Chronic exposure to wildfire smoke PM2.5 significantly increases all-cause and cause-specific mortality rates.
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Reposted by Alfred Fischer
Reiner @erlangen.bsky.social · 08/03/2026
Coffee consumption is associated with intestinal Lawsonibacter asaccharolyticus abundance and prevalence Published 18 Nov 2024 www.nature.com/articles/s41... Lawsonibacter is known as a producer of butyrate that plays an important role in intestinal health www.youtube.com/watch?v=NoWH...
nature.com
Coffee consumption is associated with intestinal Lawsonibacter asaccharolyticus abundance and prevalence across multiple cohorts - Nature Microbiology
Coffee consumption is associated with the presence and abundance of a specific member of the human gut microbiome, Lawsonibacter asaccharolyticus, and changes to the plasma metabolome.
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Alfred Fischer @alfredodistefano.bsky.social · 07/03/2026
All key aspects of sleep in this podcast. #medicine #biology podcasts.apple.com/at/podcast/g...
podcasts.apple.com
A Master Class on Sleep
Podcast-Folge · Ground Truths · 6. März · 57 Min.
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Alfred Fischer @alfredodistefano.bsky.social · 05/03/2026
The proportion of cancer deaths attributable to proximity to nuclear plants rose with age #epidemiology www.nature.com/articles/s41...
nature.com
National analysis of cancer mortality and proximity to nuclear power plants in the United States - Nature Communications
‘Populations residing near nuclear power plants may experience low-level chronic exposure to ionizing radiation through environmental release pathways. In here the authors find higher cancer mortality...
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Alfred Fischer @alfredodistefano.bsky.social · 03/03/2026
Why do we yawn? 1. Cooling effect 2. Flushing effect, discovered by these researchers. Cerebrospinal fluid is more easily removed. www.biorxiv.org/content/10.6...
biorxiv.org
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Alfred Fischer @alfredodistefano.bsky.social · 02/03/2026
SNB was not performed in only 23.4% of women ≥70 years with cT1N0, HR+ HER2- breast cancer! Data from the USA. www.together4cancer.org/digestive/co...
together4cancer.org
Commission on Cancer Quality Measure for Omission of Sentinel Lymph Node Biopsy (SNB) in Women Age 70 or Older with Hormone Receptor-Positive (HR+) Invasive Breast Cancer (IBC) Undergoing Breast-Conse...
Study focus The study evaluated how often US hospitals omit sentinel lymph node biopsy (SNB) in women ≥70 years with...
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Alfred Fischer @alfredodistefano.bsky.social · 01/03/2026
The ADCs crawl into the HR+ Breast Cancer area. #podcast podcasts.apple.com/at/podcast/p...
podcasts.apple.com
Ana C. Garrido-Castro, MD - TROP2-Targeting ADCs in the Forefront: Changing Standards and Best Practices in TNBC and HR+, HER2- Breast Cancer Care
Podcast-Folge · PeerView Clinical Pharmacology CME/CNE/CPE Audio Podcast · 24. Februar · 37 Min.
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Alfred Fischer @alfredodistefano.bsky.social · 27/02/2026
The Vienna Basin Transfer Fault System. consists of several geological faults that extend southwest from Baden near Vienna. There are fractures in the rock there, allowing warm, mineral-rich water to rise to the surface. This water is used for thermal baths and mineral water. #ilovegeology
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Alfred Fischer @alfredodistefano.bsky.social · 19/02/2026
Injectable Progestin Contraception Linked to Increased Meningioma Risk doi.org/10.1007/s110...
doi.org
Risk of intracranial meningioma requiring surgical intervention among recent hormonal contraceptives users - Journal of Neuro-Oncology
Journal of Neuro-Oncology - Progesterones have been implicated in meningioma growth. Long-acting progestin-only hormonal contraceptives (HC) are increasingly popular due to sustained serum...
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Alfred Fischer @alfredodistefano.bsky.social · 19/02/2026
Breast cancer survivors with a genetic predisposition for obesity have an increased long-term risk of death. #breast #cancer #oncology doi.org/10.1001/jama...
doi.org
Genetic Predisposition to Excess Body Weight and Breast Cancer Survival
This cohort study investigates whether there is an association between a genetic predisposition to a greater body mass index and mortality risk among US women who survived nonmetastatic breast cancer.
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Alfred Fischer @alfredodistefano.bsky.social · 19/02/2026
mRNA vaccines against TNBC. #breast #cancer www.nature.com/articles/s41...
nature.com
Individualized mRNA vaccines evoke durable T cell immunity in adjuvant TNBC - Nature
In a phase 1 trial, personalized mRNA vaccines tailored to individual tumour mutations in triple-negative breast cancer induced robust, long-lasting T cell responses and improved prognosis.
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Alfred Fischer @alfredodistefano.bsky.social · 19/02/2026
Alcohol consumption is associated with increased breast cancer incidence. Breast cancer risk increases with higher levels of alcohol consumption. www.sciencedirect.com/science/arti...
sciencedirect.com
Association between alcohol consumption and breast cancer incidence and prognosis: A systematic review and meta-analysis
While alcohol consumption appears to influence the incidence of breast cancer (BC), its association with prognosis after a BC diagnosis remains less e…
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Alfred Fischer @alfredodistefano.bsky.social · 18/02/2026
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Alfred Fischer @alfredodistefano.bsky.social · 15/02/2026
London
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Reposted by Alfred Fischer
Florian Freistetter @astrodicticum.bsky.social · 12/02/2026
Mein neues Buch "Die Farben des Universums" erscheint offiziell erst am Dienstag. Es wurde aber schon in diversen Buchhandlungen gesichtet. Ich freu mich, denn es ist ein gutes Buch 😉 www.hanser-literaturverlage.de/buch/florian...
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Alfred Fischer @alfredodistefano.bsky.social · 12/02/2026
podcasts.apple.com/at/podcast/o...
podcasts.apple.com
Early Stage Hormone Receptor Positive (HR+) Breast Cancer Treatment Algorithm: Dr. Erica Mayer
Podcast-Folge · Oncology Brothers: Practice-Changing Cancer Discussions · 12.02.2026 · 27 Min.
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Alfred Fischer @alfredodistefano.bsky.social · 11/02/2026
No, Ivermectin will not work against cancer. kffhealthnews.org/news/article...
kffhealthnews.org
US Cancer Institute Studying Ivermectin’s ‘Ability To Kill Cancer Cells’ - KFF Health News
At a January event organized by allies of health secretary Robert F. Kennedy Jr., National Cancer Institute Director Anthony Letai said results may be released “in a few months.” Ivermectin, used to d...
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Alfred Fischer @alfredodistefano.bsky.social · 11/02/2026
Tuberculosis, Chronic Bronchitis Linked to Lung Cancer Risk in Never-Smokers journal.chestnet.org/article/S001...
journal.chestnet.org
Associations between Prior Lung Diseases and Risk of Lung Cancer in Populations With No Smoking History: A Systematic Review and Meta-Analysis
History of TB and CB were associated with increased lung cancer risk among populations with no smoking history. Future studies examining these associations should analyze more diverse populations and ...
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Alfred Fischer @alfredodistefano.bsky.social · 11/02/2026
Abortion, Miscarriage Do Not Increase Risk of Breast Cancer obgyn.onlinelibrary.wiley.com/doi/10.1111/...
obgyn.onlinelibrary.wiley.com
<em>Acta Obstetricia et Gynecologica Scandinavica</em> | NFOG Women's Health Journal | Wiley Online Library
The history of induced abortion or miscarriage is not associated with an increased risk of either pre- or postmenopausal breast cancer.
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Alfred Fischer @alfredodistefano.bsky.social · 11/02/2026
In patients with idiopathic pulmonary fibrosis, the use of antifibrotic therapy was associated with a lower incidence rate and risk for lung cancer. thorax.bmj.com/content/earl...
thorax.bmj.com
Antifibrotic therapy and lung cancer risk in patients with idiopathic pulmonary fibrosis: a large retrospective propensity-weighted cohort study
Background Antifibrotic (AF) therapy has been shown to potentially reduce the risk of lung cancer (LC) in patients with idiopathic pulmonary fibrosis (IPF). Our study further assesses the impact of AF...
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Alfred Fischer @alfredodistefano.bsky.social · 09/02/2026
The efficacy of PI3K inhibition + tamoxifen beyond second-line treatment and after prior targeted therapies does not pay out #breast #cancer aacrjournals.org/clincancerre...
aacrjournals.org
PI3K inhibition in combination with tamoxifen in patients with metastatic HR+/HER2- breast cancer: clinical and circulating tumor DNA results
Abstract. Purpose: To determine the safety and efficacy of taselisib, a selective PI3K-inhibitor, in combination with tamoxifen. Patients and Methods: POSEIDON is a phaseII, randomized, placebo-contro...
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