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Alex Lu

@alexijie.bsky.social

691 followers 321 following 5 posts

Senior Researcher at Microsoft Research New England. ML/AI for biological discovery: microscopy, proteins, single-cell.

Posts Replies Media

Reposted by Alex Lu

Kevin K. Yang 楊凱筌 @kevinkaichuang.bsky.social · 17/04/2026

EnhancAR: Use evolution and deep learning to design enhancers with desired expression profiles! Had a lot of fun working with Andrew Duncan, Micaela Consens @alexijie.bsky.social @lcrawford.bsky.social Jennifer Mitchell and Alan Moses! www.biorxiv.org/content/10.6...

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Alex Lu @alexijie.bsky.social · 18/04/2026

Check out how we exploit observations of homology from evolution to design enhancers, even when we don't have prior knowledge or ability to specify function!

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Reposted by Alex Lu

Christian Dallago @machine.learning.bio · 26/02/2026

Five years ago, we released FLIP. The core question was: can ML models for protein fitness prediction generalize in the ways that actually matter for protein engineering, i.e. low data, extrapolation to more mutations, out-of-distribution sequences?

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Reposted by Alex Lu

Kevin K. Yang 楊凱筌 @kevinkaichuang.bsky.social · 25/02/2026

We made FLIP2, a protein fitness benchmark spanning seven new datasets, including enzymes, protein-protein interactions, and light-sensitive proteins, as well as splits that measure generalization relevant to real-world protein engineering campaigns.

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Alex Lu @alexijie.bsky.social · 20/11/2025

Come do a PhD internship with me!

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Alex Lu @alexijie.bsky.social · 05/07/2025

Was incredible to work with Arushi during her summer internship - check out her preprint showing that single cell representation learning methods for microscopy can be confounded by cells in the background of their inputs!

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Alex Lu @alexijie.bsky.social · 27/06/2025

Read our preprint that demonstrates a growing bias in medical imaging datasets against pediatrics, and how it impacts downstream AI development! Props to our first author @stanhua.bsky.social, who among many other feats, filtered hundreds of datasets/papers to establish this trend.

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Alex Lu @alexijie.bsky.social · 11/12/2024

At NeurIPS and interested in talking about BioML? Catch me at the Microsoft booth in the expo hall between 2:00-2:30p and 3:30-4:30p today!

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