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Alexander Tesmer

@alexandertesmer.bsky.social
31 followers 50 following 4 posts

PhD Neuroscience ‘25. Burdakov lab alumni. Metabolism and cognition in the hypothalamus.

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Alexander Tesmer @alexandertesmer.bsky.social · 02/09/2025
In mice, orexin neurons multiplex the encoding of rapid body-movements with slow changes in blood glucose. The extent to which these neurons correlate with movement across behavioral and metabolic states surprised us! Now a Version of Record in @elife.bsky.social. doi.org/10.7554/eLif...
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Reposted by Alexander Tesmer
CMC Unit @cmc-unit.bsky.social · 02/07/2025
In our Learning Club @cmc-lab.bsky.social tomorrow (= July 3rd, Thursday, 2 PM CET), @alexandertesmer.bsky.social will tell us about his recent paper (bsky.app/profile/alex...). If you'd like to attend, send an empty email to virtual-talk-link-request@cmclab.org to get the link!
pnas.org
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Alexander Tesmer @alexandertesmer.bsky.social · 12/03/2025
Hunger-driving AgRP neurons are REM-active, and similarly re-activate during cataplexy. Hot off the press from the Burdakov lab! www.biorxiv.org/content/10.1...
biorxiv.org
A rapid arousal brake on hunger neurons and its release in narcolepsy
Human sleep-wake disorders are often accompanied by eating disorders; the reasons for this apparent interplay between hunger and arousal remain unclear. Pupil-linked arousal fluctuates second-by-secon...
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Alexander Tesmer @alexandertesmer.bsky.social · 26/02/2025
Policy complexity is expensive. How does the brain regulate its investment of cognitive capacity? Our newest paper is on BioRxiv! We examine hypothalamic orexin (and MCH!) -producing neurons for their role in regulating the complexity decision policies. www.biorxiv.org/content/10.1...
biorxiv.org
Neurometabolic signaling and control of policy complexity
Cognition and adaptive behavior emerge from neural information processing. This must operate within finite metabolic constraints, since neural information processing is metabolically expensive. While ...
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Alexander Tesmer @alexandertesmer.bsky.social · 07/02/2025
Reviewed preprint is online in @elife.bsky.social: Reviewers raised some important points, revisions coming soon! Orexin population activity precisely reflects net body movement across behavioral and metabolic states doi.org/10.7554/eLif...
doi.org
Orexin population activity precisely reflects net body movement across behavioral and metabolic states
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Reposted by Alexander Tesmer
bioRxivpreprint @biorxivpreprint.bsky.social · 17/08/2024
Distinct bandwidths of orexin neuron activity independently encode body movement and metabolic state www.biorxiv.org/content/10.1101/202…
biorxiv.org
Distinct bandwidths of orexin neuron activity independently encode body movement and metabolic state https://www.biorxiv.org/content/10.1101/2024.08.13.607750v1
Hypothalamic orexin/hypocretin neurons (HONs) are key orchestrators of metabolism and adaptive behav
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