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Alina I. Sartorius @aisartorius.bsky.social · 17/03/2025

Let me know what you think – any feedback is appreciated! doi.org/10.1101/2025... All analysis code and supplementary information is publicly available on OSF 🤓 osf.io/k46gu/

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Alina I. Sartorius @aisartorius.bsky.social · 17/03/2025

These findings advance our understanding of the genetic architecture of hypothalamic subunits related to oxytocin and vasotocin and selected psychiatric/metabolic traits. We provide new avenues for future research and help decipher oxytocinergic-vasotocinergic hypothalamic systems in well-being.

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Alina I. Sartorius @aisartorius.bsky.social · 17/03/2025

The genes associated with these loci were enriched in neuroimaging, neurodegeneration and different metabolic markers. They were further found to be up-regulated in tissues such as blood vessel or down-regulated in the liver.

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Alina I. Sartorius @aisartorius.bsky.social · 17/03/2025

Subsequently, we pinpointed 95 unique loci across all subunits and traits. Most were identified for the psychiatric/metabolic traits in combination with the tubular-superior subunit, followed by the anterior-superior (displayed in the Manhattan plot), and lastly the anterior-inferior subunit.

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Alina I. Sartorius @aisartorius.bsky.social · 17/03/2025

We show that the three subunits (anterior-inferior, anterior-superior, tubular-superior) share stronger overlap with psychiatric/neurodevelopmental (autism, schizophrenia, bipolar disorder) than with metabolic (e.g., bone mineral density, BMI, HDL, LDL, systolic blood pressure) traits.

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Alina I. Sartorius @aisartorius.bsky.social · 17/03/2025

We deployed bivariate mixture models and conjunctional FDR to estimate the global and local genetic overlap between the three oxytocinergic-vasotocinergic hypothalamus subunits and ten psychiatric and metabolic traits related to oxytocin and vasotocin signaling.

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Alina I. Sartorius @aisartorius.bsky.social · 17/03/2025

Oxytocin and vasotocin are produced in the supraoptic and paraventricular nuclei within three hypothalamic subunits. The neuropeptides appear to contribute to co-occurring metabolic and psychiatric traits. The genetic pathways between these hypothalamic volumes and traits remain unknown.

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Alina I. Sartorius @aisartorius.bsky.social · 17/03/2025

New preprint! 🥳 doi.org/10.1101/2025... We delineate the genetic overlap between oxytocinergic-vasotocinergic hypothalamus subunits and psychiatric/metabolic traits, and identify novel loci jointly linked to the subunits and selected traits. 🧵⬇️

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