Eligibility for trastuzumab deruxtecan now depends on separating HER2 immunohistochemistry (IHC) score 0 from 1+ (HER2-low) and, within score 0, null...

Diagnosis of synovial sarcoma (SS) requires molecular confirmation of the SS18-SSX fusion by FISH or RT-PCR, but these methods are costly and limited...

Medulloblastoma is an embryonal tumor of the central nervous system that is divided into 3 molecular subgroups: WNT-activated, SHH-activated, and...

Clear cell sarcoma (CCS) is a rare soft tissue neoplasm characterized by melanocytic differentiation and recurrent EWSR1 rearrangements. Owing to its...

Detection of matriglycan on α-dystroglycan by immunohistochemistry is one of the essential approaches for studying the mechanisms of functional...

Dengue is an important arthropod-borne viral disease, endemic in over 100 countries and challenging health care systems worldwide São Paulo, Brasil....

Inflammatory rhabdomyoblastic tumor (IRMT) is a newly defined subtype of skeletal muscle neoplasm with uncertain malignant potential. Herein, we...

Neoadjuvant chemoradiotherapy (nCRT) is the standard treatment for locally advanced rectal adenocarcinoma, yet therapeutic response varies widely and...

This study aims to explore the influence of CD66b+ and CD8+ tumor infiltration, along with the tumoral neutrophil-lymphocyte ratio (tNLR) and blood...

Abstract was not provided for this article.

Expression of neuroendocrine differentiation (NE) markers in synovial sarcoma may result in misdiagnosis as a neuroendocrine tumor. This...

Salivary gland tumors present diagnostic challenges even to the experienced surgical pathologist due to overlap in both histologic and...

Expression of neuroendocrine differentiation (NE) markers in synovial sarcoma may result in misdiagnosis as a neuroendocrine tumor. This...

Cancer is one of the leading causes of morbidity and mortality worldwide, with lung cancer ranked among the most lethal malignancies. A key hallmark...

Preferentially expressed antigen in melanoma (PRAME) expression has been described in Merkel cell carcinoma (MCC), but its clinicopathologic and...

The use of ready-to-use (RTU) antibodies in pathology laboratories has increased due to regulatory changes and the need for standardized, efficient...

c-MET is a promising therapeutic target in non-small cell lung cancer (NSCLC). This necessitates accurate detection of c-MET aberrations for...

Programmed death-ligand 1 (PD-L1) is a predictive biomarker in various cancers. In colorectal cancer, PD-L1 expression evaluation is not part of the...

The expression of members of the GATA family of proteins and their prognostic value has been previously investigated in different tissues; however,...

Background:Breast cancer is the most common form of cancer diagnosed in women. Breast cancer cells gain the expression of mesenchymal-specific genes...

Patient-derived organoids (PDOs) offer a powerful in vitro platform to model cancer biology, investigate therapeutic responses, and personalize...

Rosai-Dorfman disease (RDD) is a rare sinus histiocytosis characterized by massive lymphadenopathy. The purpose of this study was to retrospectively...

Uterine endometrioid carcinoma (UEC) is the most common subtype of endometrial cancer. This study aimed to investigate the prognostic relevance of...

nti-PD1 therapy were included. Histologic subtypes were assessed on hematoxylin and eosin-stained slides; PD-L1 expression was evaluated using conventional immunohistochemistry; the immune microenviro...

(or medullary-like) RCC, which is aggressively treated with chemotherapy, primarily platinum-based. In contrast, a distinct set of agents, such as the combination of bevacizumab and erlotinib, is the ...