Communications Chemistry, Published online: 18 April 2026; doi:10.1038/s42004-026-02033-3Selective protein functionalization remains difficult to achieve through conventional molecular biology approaches. Here, the authors summarize recent advances in chemical approaches to protein engineering and highlight their emerging applications in catalysis, functional studies, and therapeutic development.

The synthesis of two [1H]/[2H] discriminated bianthryl atropisotopomers (i.e., isotopically chiral atropisomers, vide infra) with ≥97% enantiomeric excess (ee) from the atropisomers of commercial (aS)...

In this review, we spotlight recent breakthroughs in α-polyboron-substituted carbon-centered intermediates (carbanion, carbocation, radical, and carbene) and polyborylated alkenes. By bridging fundam...

Second-order rate constants and thermodynamic activation parameters for the strain-promoted oxidation-controlled quinone (SPOCQ) click reaction of an ortho-quinone with various trans-cyclooctene and c...