iiinova — where your digital self keeps evolving

Reposted by Anders Granholm

Marion Campbell @marionkcampbell.bsky.social · 16/06/2025

At #CCR25, we saw some trials use a #CompositeOutcome (an endpoint that combines more than one outcome into a single measure) & also saw some of the problems these can throw up. I have discussed these before but thought it would be useful to revisit 1/9 #MethodologyMonday #120

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Anders Granholm @agranholm.bsky.social · 21/03/2025

Interested in adaptive platform trials? INCEPT (www.incept.dk) recently got approved along with the first domain, and we expect to start inclusion soon. A protocol/design paper is available at doi.org/10.1111/aas.... along with the full protocol docs at incept.dk/documents @andersperner.bsky.social

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Reposted by Anders Granholm

Marion Campbell @marionkcampbell.bsky.social · 24/02/2025

This past month has seen the publication of a couple of new helpful papers providing further insights into the thorny issue of #MultipleTesting in trials 1/7 #MethodologyMonday #112

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Reposted by Anders Granholm

Anders Perner @andersperner.bsky.social · 23/02/2025

Good news for ICUs and patients The Intensive Care Platform Trial - INCEPT - was approved by the regulators INCEPT is a very broad domain based, adaptive platform trial assessing everyday interventions in ICUs 1. enrolled in first domain (albumin use vs no use in shock) in april 2025 incept.dk

incept.dk

The Intensive Care Platform Trial (INCEPT) research programme aims to prepare, initiate and run an adaptive platform trial assessing commonly used interventions in acutely ill intensive care unit (ICU) patients.

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Marion Campbell @marionkcampbell.bsky.social · 27/01/2025

An issue that often comes up is how to set a “non-inferiority margin” in a non-inferiority trial and how to ensure it is appropriate 1/8 #MethodologyMonday #109

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Reposted by Anders Granholm

Anders Granholm @agranholm.bsky.social · 16/01/2025

Interested in design and evaluation of advanced adaptive trial designs? See our new preprint: doi.org/10.48550/arX... Here we summarise key methodological considerations and how to specify and evaluate them using simulations via our 'adaptr' #Rstats package (inceptdk.github.io/adaptr/) 1/..

doi.org

Designing and evaluating advanced adaptive randomised clinical trials: a practical guide

Background Advanced adaptive randomised clinical trials are increasingly used. Compared to their conventional counterparts, their flexibility may make them more efficient, increase the probability o...

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Anders Granholm @agranholm.bsky.social · 16/01/2025

doi.org

Designing and evaluating advanced adaptive randomised clinical trials: a practical guide

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Peter Nydahl @nydahlpeter.bsky.social · 07/01/2025

A Core Outcome Set for Adult General ICU Patients should include survival, free of life support, free of delirium, out of hospital, health-related quality of life, and cognitive function. Excellent international Delphi study from Denmark journals.lww.com/ccmjournal/f...

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Reposted by Anders Granholm

Anders Perner @andersperner.bsky.social · 08/01/2025

A core outcome set for general ICU patients aimed for clinical trials - developed with many stakeholder and internationally validated Amazing work by #INCEPT trial team led by @maj-brit.bsky.social with contribution from a large group of international colleagues journals.lww.com/ccmjournal/a...

journals.lww.com

A Core Outcome Set for Adult General ICU Patients : Critical Care Medicine

nts exist, for example, respiratory failure, delirium, and COVID-19, but not for ICU patients in general. Accordingly, we aimed to develop a core outcome set for adult general ICU patients. Design: ...

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Reposted by Anders Granholm

Darren Dahly @statsepi.bsky.social · 12/11/2024

In clinical research, you will often receive feedback on study design, stats, and/or data analysis from an editor or reviewer that is simply wrong. Here is a list of common "statistical myths" and references you can use to push back. discourse.datamethods.org/t/reference-...

discourse.datamethods.org

Reference Collection to push back against "Common Statistical Myths"

Note: This topic is a wiki, meaning that this main body of the topic can be edited by others. Use the Reply button only to post questions or comments about material contained in the body, or to sugge...

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Lars Mølgaard Saxhaug @load-dependent.eurosky.social · 12/11/2024

This is a list of statistical myths and misconceptions that I keep coming back to. So many common avoidable mistakes. Should be read by all clinician researchers and all who want to critically read studies! #cardiosky #emimcc #stats

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