iiinova — where your digital self keeps evolving

Aleksandra Galitsyna @agalicina.bsky.social · 21/09/2026

Pleased to contribute analysis to this comprehensive study first-authored by Xiangru Huo. Exceptional effort and coordination to map the intricate details of stem cell differentiation into hepatocyte-like cells. Read the full paper below 👇

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Reposted by Aleksandra Galitsyna

Mark Peifer (He, him) @peiferlabunc.bsky.social · 19/09/2026

An incredible effort to chart how the genome reorganizes from chromosome to the DNA contacts scales as a stem cell differentiates. Lot's of new insights here! 🧪

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Aleksandra Galitsyna @agalicina.bsky.social · 09/02/2026

One of the first in vivo demonstrations that cohesin loss in non-dividing cells can hit hard physiologically, impairing immune function of dendritic cells in mouse. Out in Science Immunology, major contributors: @nickadams-phd.bsky.social, Boris Reizis, Leonid Mirny www.science.org/doi/10.1126/...

science.org

Cohesin-mediated chromatin organization controls the differentiation and function of dendritic cells

Chromatin-organizing cohesin complex cooperates with transcription factor IRF8 to enable the functionality of dendritic cells in vivo.

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Reposted by Aleksandra Galitsyna

Nick Adams @nickadams-phd.bsky.social · 07/02/2026

Excited to share our work published yesterday (and featured on the cover!) of #ScienceImmunology. This was a true team effort between the Reizis lab at NYU @uchicagocoi.bsky.social and Sasha Galitsyna & Leonid Mirny at MIT 1/ www.science.org/doi/10.1126/...

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Reposted by Aleksandra Galitsyna

Job Dekker @jobdekker.bsky.social · 03/02/2026

Terrific paper on a new chromosomal compartment where extensive loop extrusion isolates domains from other such domains

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Aleksandra Galitsyna @agalicina.bsky.social · 26/01/2026

Have you wondered how the rules of chromatin folding have evolved? Well, this task is not easy to formalize. But here is our take on it: train species-specific DNA-to-chromatin encoder, apply to DNA of unseen species, and build chromatin rules-based tree of life. Have a look: doi.org/10.1093/nar/...

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Aleksandra Galitsyna @agalicina.bsky.social · 24/01/2025

Three-dimensional organization of amoeba Dictyostelium discoideum has fascinating features! Very prominent dots at between convergent gene positions, something never really seen for other species. More about the puzzle and how the team of my PhD colleagues resolves it: doi.org/10.1093/nar/...

doi.org

Convergent pairs of highly transcribed genes restrict chromatin looping in Dictyostelium discoideum

Abstract. Dictyostelium discoideum is a unicellular slime mold, developing into a multicellular fruiting body upon starvation. Development is accompanied b

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