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Cellular and Molecular Gastroenterology and Hepatology (CMGH) @aga-cmgh.bsky.social · 16/10/2026

UPenn scientists from the Kaestner lab derived a new mouse model, the SenKiller mouse, for selective ablation of specific senescent cells for the study of the role of senescence in disease etiology. 🔗 ow.ly/K6aK50ZXEJR 🏷️ #FeaturedArticle

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Cellular and Molecular Gastroenterology and Hepatology (CMGH) @aga-cmgh.bsky.social · 15/10/2026

Check out the new #EditorsEssentialReading ➡️ "Thymic Stromal Lymphopoietin–Driven B-Cell Hyperactivation Impairs Intestinal Epithelial Homeostasis Predisposing to Enterocolitis in Hirschsprung Disease" 🔗 ow.ly/Hwjz50ZXAvf

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Cellular and Molecular Gastroenterology and Hepatology (CMGH) @aga-cmgh.bsky.social · 08/10/2026

Check out this original research article ➡️ "Hepatocyte Transforming Growth Factor-β–Oxysterol-Binding Protein-Related Protein 3 Signaling Axis Promotes Hepatic Stellate Cell Activation and Liver Fibrogenesis in Mice" 🔗 ow.ly/NmN650ZUHKW

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Cellular and Molecular Gastroenterology and Hepatology (CMGH) @aga-cmgh.bsky.social · 07/10/2026

📑 B.acidifaciens attenuates liver damage by remodeling bile acids to suppress CD95-mediated hepatocyte apoptosis. 🔗 ow.ly/FRbX50ZUHAS 🏷️ #GIHealth #GITwitter

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Cellular and Molecular Gastroenterology and Hepatology (CMGH) @aga-cmgh.bsky.social · 06/10/2026

This article identifies HMGA2 as a key oncogenic driver of iCCA growth and metastasis. IGF2BP1 positively regulates HMGA2 expression via m⁶A modification, with the axis promoting PI3K-AKT pathway activation. 🔗 ow.ly/hZEz50ZUHue

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Cellular and Molecular Gastroenterology and Hepatology (CMGH) @aga-cmgh.bsky.social · 30/09/2026

Inflammation and thrombosis play crucial roles in pancreatic necrosis. Targeting ADAMTS13 activity enhancement with the combination of PAD4 inhibition may better alleviate acute pancreatitis. 🔗 ow.ly/6Olg50ZSVm8

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Cellular and Molecular Gastroenterology and Hepatology (CMGH) @aga-cmgh.bsky.social · 25/09/2026

➡️ Inflammation and thrombosis play crucial roles in pancreatic necrosis. Targeting ADAMTS13 activity enhancement with the combination of PAD4 inhibition may better alleviate acute pancreatitis. 🔗 ow.ly/9xQ150ZQz46

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Cellular and Molecular Gastroenterology and Hepatology (CMGH) @aga-cmgh.bsky.social · 24/09/2026

➡️ "Triggering Receptor Expressed on Myeloid Cells 2+ Macrophages Promote Pancreatic Regeneration Through Cholesterol–Metabolism Reprogramming and Hedgehog Signaling Activation Following Acute Pancreatitis" 🔗 ow.ly/Ja4350ZQz02 🏷️ #FeaturedArticle

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Cellular and Molecular Gastroenterology and Hepatology (CMGH) @aga-cmgh.bsky.social · 23/09/2026

Check out this #FeaturedArticle ➡️ "Coordinated Interferon-γ/Tumor Necrosis Factor Axis Drives Selective Loss of Activated Enteric Glia in Inflammatory Bowel Diseases" 🔗 ow.ly/vjMw50ZQyUc

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Cellular and Molecular Gastroenterology and Hepatology (CMGH) @aga-cmgh.bsky.social · 18/09/2026

➡️ How diet influences IBD is poorly understood. Gray et al. show that dietary protein source impacts the severity of experimental colitis, mediated by bacterial modulation of bile acids. 🔗 ow.ly/RNuh50ZOi3C 🏛️ Renaissance School of Medicine at Stony Book University 🏷️ #FeaturedArticle #IBD

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Cellular and Molecular Gastroenterology and Hepatology (CMGH) @aga-cmgh.bsky.social · 17/09/2026

📑 Prior intestinal inflammation shapes future disease outcomes. Infectious and chemical colitis leave distinct epithelial and immune imprints that promote protection or susceptibility. 🔗 ow.ly/70vb50ZOhVy 🏷️ #FeaturedArticle

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Cellular and Molecular Gastroenterology and Hepatology (CMGH) @aga-cmgh.bsky.social · 17/09/2026

#PeerReviewWeek 🎉 CMGH recognizes Dr. Naim Alkhouri as one of our top reviewers! Through thoughtful, constructive reviews, he has helped authors strengthen their manuscripts and advance high-quality science. Thank you for your dedication to peer review! 🔗 ow.ly/t7aU50ZOspj

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Cellular and Molecular Gastroenterology and Hepatology (CMGH) @aga-cmgh.bsky.social · 16/09/2026

The newest issue from CMGH is available now! Check out the #EditorsEssentialReading ➡️ " Current Practices and Considerations for Benchmarking Human Gastrointestinal Organoids" 🔗 ow.ly/g8LC50ZOhQQ

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Cellular and Molecular Gastroenterology and Hepatology (CMGH) @aga-cmgh.bsky.social · 11/09/2026

➡️ A novel multiphoton endomicroscopy-based approach shows that disruption of the gut–vascular barrier and increased vascular permeability precede classical inflammation markers in colitis. 🔗 ow.ly/KlLg50ZLAef 🏷️#GutHealth #GITwitter #FeaturedArticle

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Cellular and Molecular Gastroenterology and Hepatology (CMGH) @aga-cmgh.bsky.social · 10/09/2026

📑 What triggers CRC invasion? PTEN haploinsufficiency activates PI3K–mTORC1 and drives invasion in a CDX2P-Cre-based mouse model. Human biopsies show PI3K alterations at the invasive transition. 🔗 ow.ly/cVKQ50ZLA7o 🏷️ #CRC #GITwitter

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Cellular and Molecular Gastroenterology and Hepatology (CMGH) @aga-cmgh.bsky.social · 03/09/2026

📑 In this newly published article, a new method that allows conditional ablation of two linked but non-contiguous genes which can be useful for complex loci. 🔗 ow.ly/n71B50ZHKJ6 👨‍⚕️ Klaus Kaestner 🏷️ #TechnicalAdvances #GITwitter

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Cellular and Molecular Gastroenterology and Hepatology (CMGH) @aga-cmgh.bsky.social · 02/09/2026

📑 Issues affecting interpretation of studies of microbiota/ENS interactions given recent transcriptomic data and the diversity of GI functions are reviewed, highlighting often overlooked questions. 🔗 ow.ly/Rpvc50ZHKwu 🏷️ #GutMicrobiota #GITwitter #BriefReview

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Cellular and Molecular Gastroenterology and Hepatology (CMGH) @aga-cmgh.bsky.social · 01/09/2026

📑 Dietary tryptophan restores microbiota-dependent AhR activation and reduces colitis severity, highlighting a potential diet-microbe approach for IBD management. 🔗 ow.ly/nCmL50ZHKnS 🏷️ #IBD #GITwitter

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Cellular and Molecular Gastroenterology and Hepatology (CMGH) @aga-cmgh.bsky.social · 27/08/2026

📑 CBP/p300 maintain hepatic bile acid homeostasis by directly activating BSEP transcription via H3K27 acetylation and inducing KLF10, which also promotes BSEP. 🔗 ow.ly/gGsU50ZF09T 🏷️ #GITwitter #Metabolism

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Cellular and Molecular Gastroenterology and Hepatology (CMGH) @aga-cmgh.bsky.social · 26/08/2026

In this research article, the group of authors identify a CagA–OTUB2–YAP axis linking Helicobacter pylori infection to gastric epithelial reprogramming. YAP drives junctional disruption and chief cell–derived metaplasia. 🔗 ow.ly/rcfY50ZF07O 🏷️ #GITwitter

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Cellular and Molecular Gastroenterology and Hepatology (CMGH) @aga-cmgh.bsky.social · 25/08/2026

📑 Intestinal SIRT1 drives liver regeneration via the FXR/FGF15 axis. Its loss disrupts bile acid homeostasis, reduces hepatocyte proliferation, and increases injury. 🔗 ow.ly/ftRK50ZF05m 🏷️ #LiverHealth #GITwitter

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Cellular and Molecular Gastroenterology and Hepatology (CMGH) @aga-cmgh.bsky.social · 21/08/2026

📑 This study defines a new inflammatory axis in acute pancreatitis, where Kupffer cell–derived exosomal S100A8/A9 induces alveolar macrophage pyroptosis by disrupting HSP70-dependent lysosomal function. 🔗 ow.ly/kwNZ50ZB8Zi 🏷️ #FeaturedArticle

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Cellular and Molecular Gastroenterology and Hepatology (CMGH) @aga-cmgh.bsky.social · 20/08/2026

👀 Scientists uncover how a blood vessel protein (Heg1) signals to liver cells to control fat burning. When this crosstalk fails, fat builds up, highlighting a promising target for fatty liver disease. 🔗 ow.ly/o8NO50ZB8YH 🏷️ #FeaturedArticle

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Cellular and Molecular Gastroenterology and Hepatology (CMGH) @aga-cmgh.bsky.social · 19/08/2026

Check out the Editor's Essential Reading from the latest issue ➡️ "Mucosal-Associated Invariant T Cells Drive Bile Duct Inflammation" 🔗 ow.ly/SJgp50ZB8XN 🏷️ #GutHealth #EditorsEssentialReading

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Cellular and Molecular Gastroenterology and Hepatology (CMGH) @aga-cmgh.bsky.social · 17/08/2026

👩‍⚕️ Introducing the Early Career Reviewer Panel! We're thrilled to welcome these members as they learn reviewer skills, work with expert mentors, and establish themselves as expert reviewers. Meet the panel: ow.ly/NQfa50Zzxcj Congratulations to our 2026-2027 cohort! 🎉

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Cellular and Molecular Gastroenterology and Hepatology (CMGH) @aga-cmgh.bsky.social · 13/08/2026

📑 Current study underscores the role of liver stroma in liver pathology. Specifically, Msln/Muc16 signaling in portal fibroblasts contributes to age-related progression of cholestatic fibrosis and HCC 🔗 ow.ly/jxzi50ZwlKl 🏷️ #Fibrosis #LiverDisease

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Cellular and Molecular Gastroenterology and Hepatology (CMGH) @aga-cmgh.bsky.social · 11/08/2026

🐭 New mouse model for severe pediatric liver disease provides insights in disease mechanism and options for treatment. 🔗 ow.ly/Y0IO50Zwlu7 🏷️ #GIHealth

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Cellular and Molecular Gastroenterology and Hepatology (CMGH) @aga-cmgh.bsky.social · 07/08/2026

➡️ The hypertrophic mesenteric adipose tissue and formation of creeping fat of Crohn’s disease exhibited disturbed oxylipin metabolism which is correlated with the development of gut inflammation. 🔗 ow.ly/BoUF50ZwjgE 🏷️ #CrohnsDisease

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Cellular and Molecular Gastroenterology and Hepatology (CMGH) @aga-cmgh.bsky.social · 05/08/2026

⭐ This review summarizes how intermittent fasting counteracts high‑fat, high‑sugar diet– and obesity‑induced mitochondrial and gut barrier dysfunction to restore gut–brain axis function. 🔗 ow.ly/29Pw50Zwja9 🏷️ #Obesity #GutBrainAxis

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Cellular and Molecular Gastroenterology and Hepatology (CMGH) @aga-cmgh.bsky.social · 05/08/2026

📑 This study shows that senescent CAFs in human PDAC coexpress myCAF/iCAF markers and enrich at the tumor edge, and their SASP-related signaling may promote tumor growth and invasion. 🔗 ow.ly/Th9q50ZwiK0 🏷️ #PancreaticCancer

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Cellular and Molecular Gastroenterology and Hepatology (CMGH) @aga-cmgh.bsky.social · 30/07/2026

➡️ Deleting BMAL1 in hepatocytes disrupts liver circadian rhythms, impairs cholesterol metabolism, and worsens MASH in mice. Human data support circadian disruption in disease progression. 🔗 ow.ly/hsY250ZtwMK 🏷️ #LiverHealth

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Cellular and Molecular Gastroenterology and Hepatology (CMGH) @aga-cmgh.bsky.social · 29/07/2026

⭐ FEATURED ARTICLE ⭐ 📑 "Microbial Monotherapy With Leuconostoc sp LB-P8 Improves Inflammation and Fibrosis in Mouse Primary Sclerosing Cholangitis by Inhibiting Transforming Growth Factor β1/SMAD Signaling" 🔗 ow.ly/w1uQ50ZtwEf 🏷️ #FeaturedArticle #LiverDisease

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Cellular and Molecular Gastroenterology and Hepatology (CMGH) @aga-cmgh.bsky.social · 28/07/2026

📑 Whelan Lab identifies IL-13/JAK/STAT as a primary mediator of mitochondrial accumulation in esophageal keratinocytes and demonstrates increased circulating mtDNA in EoE patients. 🔗 ow.ly/VhFs50Zto2X 🏷️ #GIHealth

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Cellular and Molecular Gastroenterology and Hepatology (CMGH) @aga-cmgh.bsky.social · 23/07/2026

👩‍⚕️Did you know CMGH launched a section on training, mentoring, and education? Learn more ⬇️ ⚪Mentoring Trainees in This New Scientific Research Landscape: How Can We Help? ow.ly/QvSE50ZqTf9 ⚪“Can Everyone Hear Me?” Lessons on Educating Post-2020 ow.ly/1YRg50ZqT65

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Cellular and Molecular Gastroenterology and Hepatology (CMGH) @aga-cmgh.bsky.social · 17/07/2026

➡️ In this study, we found that the recently identified oncogene VPS35 is not a typical oncogene and that VPS35 deficiency even increases hepatocellular proliferation in postnatal livers. 🔗 ow.ly/Payv50Zo1Lc 🏷️ #LiverCancer #FeaturedArticle

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Cellular and Molecular Gastroenterology and Hepatology (CMGH) @aga-cmgh.bsky.social · 16/07/2026

Check out the Editor's Essential Reading ⭐ "Enteral Feeding With Omega-3 Polyunsaturated Fatty Acids Mitigates Liver Injury Following Massive Intestinal Resection" ⭐ 🔗 ow.ly/zAPM50Zo1IR 🏷️ #EditorsEssentialReading #ShortBowelSyndrome

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Cellular and Molecular Gastroenterology and Hepatology (CMGH) @aga-cmgh.bsky.social · 15/07/2026

⭐ The newest issue of CMGH is here! ⭐ Don't miss the latest research shaping the future of digestive health. Follow us for monthly featured articles, editor picks, and standout discoveries. 👀 🔗 ow.ly/mH7I50ZnTVJ 🏷️ #GIResearch #Gastroenterology #Hepatology #OpenAccess

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Cellular and Molecular Gastroenterology and Hepatology (CMGH) @aga-cmgh.bsky.social · 09/07/2026

✉️ Check out this research letter ➡️ "Transcriptomics of Upper Gastrointestinal Fluids Can Diagnose Pancreatic Ductal Adenocarcinoma" 🔗 ow.ly/4bvQ50Zle8w 🏷️ #ResearchLetter #GIHealth

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Cellular and Molecular Gastroenterology and Hepatology (CMGH) @aga-cmgh.bsky.social · 07/07/2026

⭐ Check out this narrative review ➡️ "Conserved Ductular Reaction Mechanisms in Biliary Atresia and Primary Sclerosing Cholangitis Derived From Single-Cell and Spatial Transcriptomics" 🔗 ow.ly/r1lM50Zle4v 🏷️ #NarrativeReview #GIHealth

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Cellular and Molecular Gastroenterology and Hepatology (CMGH) @aga-cmgh.bsky.social · 02/07/2026

This study shows inflammatory memory in patients with Inflammatory Bowel Disease. Check it out ⬇️ 🔗 ow.ly/Q0QN50ZitHZ 🏷️ #IBD #GIHealth

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Cellular and Molecular Gastroenterology and Hepatology (CMGH) @aga-cmgh.bsky.social · 01/07/2026

Stem cell marker MEX3A drives colorectal cancer growth, repressing PPARG-mediated differentiation, and its loss enhances patient tumoroids sensitivity to chemotherapy. 🔗 ow.ly/zbpq50ZitCu 🏷️ #RNA #organoids #cancer

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Cellular and Molecular Gastroenterology and Hepatology (CMGH) @aga-cmgh.bsky.social · 30/06/2026

📑 This study shows that iPSC-derived human intestinal organoids can be enriched for Paneth cells and demonstrates that responses to cytokines, microbes and microbial ligands can be quantified. 🔗 ow.ly/NsBG50ZitBV 🏷️ #GutHealth #GI

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Cellular and Molecular Gastroenterology and Hepatology (CMGH) @aga-cmgh.bsky.social · 18/06/2026

CMGH has received a 2025 Impact Factor of 8.2! On behalf of Editors-in-Chief Jonathan Katz & Michele Battle, thank you to our editors, authors, reviewers, and readers for your continued support. ow.ly/6wcZ50Zeo1F American Gastroenterological Association (AGA)

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Just released: AGA journals receive new Impact Factor scores

The American Gastroenterological Association (AGA) is the trusted voice of the GI community. AGA publishes top-tier journals, guidelines and patient education ...

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Cellular and Molecular Gastroenterology and Hepatology (CMGH) @aga-cmgh.bsky.social · 18/06/2026

⭐ Check out this article form latest issue! 📑 "Glial Connexin-43 Is a Pathogenic Mechanism Promoting Gut Inflammation in Postoperative Ileus Induced by Gut Surgical Manipulation With Potential Relevance to Humans" 🔗 ow.ly/JTLO50Zc1I7 🏷️ #FeaturedArticle

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Cellular and Molecular Gastroenterology and Hepatology (CMGH) @aga-cmgh.bsky.social · 17/06/2026

🔬 This team reveals a hepatocyte UBE2O/YBX1/IL‑6 axis that shifts Treg/Th17 balance, offering new insight into autoimmune hepatitis pathogenesis 🔗 ow.ly/Jq9P50Zc0Ws 🏷️ #FeaturedArticle #AutoimmuneHepatitis #AIH

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Cellular and Molecular Gastroenterology and Hepatology (CMGH) @aga-cmgh.bsky.social · 16/06/2026

📑CMGH's latest Editor's Essential Reading is here! ⭐ "Interleukin 6 Drives Durable T Cell-Mediated Immunity to Pancreatic Cancer" 🔗 ow.ly/J2TB50Zc0Np 🏷️ #EditorsEssentialReading #PancreaticCancer

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Cellular and Molecular Gastroenterology and Hepatology (CMGH) @aga-cmgh.bsky.social · 11/06/2026

⭐ New findings reveal high-risk cells in "low-grade" pancreatic cysts, marked by cancer genes like KRT17, which could help predict which cysts may become cancerous. 🔗 ow.ly/MAT050Z94GS

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Cellular and Molecular Gastroenterology and Hepatology (CMGH) @aga-cmgh.bsky.social · 10/06/2026

Check out this research letter ➡️ "Sphingosine-1-Phosphate Receptor 5 Signaling Is Redundant in Preclinical Models of Inflammatory Bowel Disease" 🔗 ow.ly/bTZ050Z94yq 🏷️ #IBD

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