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Ari Firestone

@afirestone.bsky.social

23 followers 22 following 13 posts

Dad and Scientist Oncology early discovery @calico Richmond CA

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Reposted by Ari Firestone

bioRxiv Cancer Bio @biorxiv-cancer.bsky.social · 09/05/2026

Dependencies in heterogeneous, lineage plastic patient-derived prostate cancer organoids revealed through integrated single-cell multiomics and CRISPR screening www.biorxiv.org/content/10.64898/20…

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Ari Firestone @afirestone.bsky.social · 15/04/2026

New preprint! We built MAJEC a tool that jointly quantifies genes, isoforms, and individual transposable element loci from RNA-seq. It replaces 3 tools, runs fast, and uncovered a contamination problem affecting ~40% of locus-level TE signal.

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Ari Firestone @afirestone.bsky.social · 16/02/2026

Microsatellite instable cancer cells acquire on-target resistance mutations to WRN helicase inhibitors url: aacrjournals.org/mct/article/...

aacrjournals.org

Microsatellite instable cancer cells acquire on-target resistance mutations to WRN helicase inhibitors

Abstract. The Werner syndrome helicase (WRN) is a promising target for cancers with microsatellite instability (MSI) leading to the initiation of at least five Phase I clinical trials. Acquired resist...

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Reposted by Ari Firestone

Sciences @sciences.skyfleet.blue · 04/10/2023

The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity

nature.com

The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity - Nature

An orally bioavailable small-molecule active-site inhibitor of the phosphatases PTPN2 and PTPN1, ABBV-CLS-484, demonstrates immunotherapeutic efficacy in mouse models of cancer resistant to PD-1 blockade.

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