adrinnenberg.bsky.social @adrinnenberg.bsky.social · 13/11/2025Then came a surprise: While mapping these circuits, we found neurons robustly recruited by the stimulation of many different, non-overlapping excitatory ensembles. We named them General Ensemble-Response (GER) neurons. 7/13 110
adrinnenberg.bsky.social @adrinnenberg.bsky.social · 13/11/2025In a different strategy, we decouple transgenic opsin expression from dense viral indicator expression, enabling read-write access to >1,000 neurons and read access to 10,000 neurons in a single acquisition volume 🤯 5/13 100
adrinnenberg.bsky.social @adrinnenberg.bsky.social · 13/11/2025The transgenics allow for reliable holographic stimulation of large cortical ensembles with minimal power (<10 mW time-averaged power for 60 simultaneous targets). 4/13 100
adrinnenberg.bsky.social @adrinnenberg.bsky.social · 13/11/2025We developed new fully-transgenic all-optical tools for robust and layer-specific read/write access across cortex. No viral injections needed. Stable, well-balanced, and wide-spread co-expression of soma-enriched ChRmine and indicator. 3/13 110
