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Serini Lab

@adhynamic.bsky.social
171 followers 212 following 7 posts

Our lab aim is to grasp the molecular mechanisms by which cells adhere to and move through the body environment in cancer, vascular and rare genetic diseases. www.dep-oncology.unito.it/do/docent…

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Serini Lab @adhynamic.bsky.social · 23/02/2025
Glad to share our last manuscript on a luminescent sensor we created to unveil novel potentially actionable regulators of β1 integrin activation in vascular endothelial cells and angiogenesis. @cp-cellreports.bsky.social www.cell.com/cell-reports...
• β1 integrin activation sensor (β1IAS) reports β1 integrin activation in response to biochemical and physical stimuli

• siRNA HTS on β1IAS KI endothelial cells unveils unknown regulators of β1 integrin activation

• E3 ubiquitin ligase Pja2 promotes kindlin-2 degradation and inhibits β1 integrin activation

• VEGF-B is a so far unrecognized effective inhibitor of β1 integrin activation
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