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Structural Biology Communications @actacrystf.iucr.org · 07/09/2026

Our September issue is out! journals.iucr.org/f/issues/202... The cover shows the structure of the NKX2-1 homeodomain bound to a 19 bp DNA duplex containing two palindromically arranged NK2-recognition motifs. Read more at doi.org/10.1107/S205...

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Structural Biology Communications @actacrystf.iucr.org · 27/08/2026

WebCalEM is a browser-based tool that makes lattice-based pixel-size calibration a routine step in the cryo-EM workflow #CryoElectronMicroscopy #MagnificationCalibration #PixelSize doi.org/10.1107/S205...

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Structural Biology Communications @actacrystf.iucr.org · 26/08/2026

The replacement of DTT with TCEP in the crystallization of human aldehyde oxidase provides a strategy to circumvent enzyme inactivation during crystallographic studies #HumanAldehydeOxidase #XRayCrystallography #TCEP doi.org/10.1107/S205...

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Structural Biology Communications @actacrystf.iucr.org · 25/08/2026

The crystal structure of LegY, a putative glycosidase effector from L. pneumophila, was determined to 1.46 Å resolution and is structurally assigned as a member of glycoside hydrolase family 15 #LegionellaPneumophila #BacterialToxin #Glycosidase doi.org/10.1107/S205...

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Structural Biology Communications @actacrystf.iucr.org · 24/08/2026

We would like to invite you to share protocols that will be useful to the community, and help maintain Acta Crystallographica Section F and and the other IUCr Journals as important references for how structural biology research is performed doi.org/10.1107/S205...

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Structural Biology Communications @actacrystf.iucr.org · 13/08/2026

Presenting the first article in our new 'Protocols' category: Helical reconstruction of amyloids in cryoSPARC #Amyloids #CryoEM #HelicalReconstruction doi.org/10.1107/S205...

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Structural Biology Communications @actacrystf.iucr.org · 12/08/2026

The crystal structure of human DKK4-CRD1 determined at 1.83 Å resolution reveals a compact fold comprising N- and C-subdomains connected by a linker region and stabilized by five conserved disulfide bonds #WntSignaling #Dickkopf4 #CysteineRichDomain1 doi.org/10.1107/S205...

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Structural Biology Communications @actacrystf.iucr.org · 11/08/2026

The DUF2875 domain-containing T6SS adaptor protein Tla3 from Pseudomonas aeruginosa strain UCBPP-PA14 shows a thiolase-like fold, marked by a five-layered α–β–α–β–α core topology #T6SS #Adaptors #PseudomonasAeruginosa doi.org/10.1107/S205...

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Structural Biology Communications @actacrystf.iucr.org · 10/08/2026

The cytosolic Nudix-like domain of the CBASS effector EfCap16 from E. faecalis was determined. The characteristic Nudix-like fold supports classification of EfCap16 as a member of the Nudix superfamily #CBASS #NudixHydrolases #TransmembraneEffectors doi.org/10.1107/S205...

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Structural Biology Communications @actacrystf.iucr.org · 06/08/2026

August issue is out! journals.iucr.org/f/issues/202... On the cover: the crystal structure of LegY, a putative glycosidase effector from Legionella pneumophila, shows high similarity to fungal glucoamylases but shares lower homology with known prokaryotic counterparts doi.org/10.1107/S205...

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Structural Biology Communications @actacrystf.iucr.org · 30/07/2026

A new type of article for Acta F: Protocols The purpose of this new category is to provide to the reader procedures that are sufficiently detailed so other researchers can reproduce the described workflow. Find out more in 'Show me how it's done: introducing Protocols': doi.org/10.1107/S205...

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Structural Biology Communications @actacrystf.iucr.org · 29/07/2026

We're celebrating 20 years of Acta Crystallographica Section F!🎉🥳 Join us by contributing to our celebratory collection of articles, which is now open for submissions! Find out more at journals.iucr.org/special_issu...

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Structural Biology Communications @actacrystf.iucr.org · 15/07/2026

A crystal structure of PLpro exhibits Ubl2 in two distinct conformations: the well characterized closed state, where Ubl2 is positioned near the PLpro domain, and an as yet uncharacterized open state #SARSCoV2 #PapainLikeProteases #Ubl2Domain doi.org/10.1107/S205...

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Structural Biology Communications @actacrystf.iucr.org · 14/07/2026

A new crystal structure of ApePCNA1 and the newly solved structure of the ApePCNA2 homotrimer allowed modeling of the ApePCNA1–ApePCNA2–ApePCNA3 heterotrimer #AeropyrumPernix #DNAReplication #ProliferatingCellNuclearAntigens doi.org/10.1107/S205...

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Structural Biology Communications @actacrystf.iucr.org · 13/07/2026

The crystal structure of GABA aminotransferase from A. thaliana and structural comparison supports the conclusion that it belongs to the class III aminotransferase family #ArabidopsisThaliana #CrystalStructure #GABAAminotransferase doi.org/10.1107/S205...

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Structural Biology Communications @actacrystf.iucr.org · 09/07/2026

The molecular interactions of the insomnia drug vorenorexant with human orexin receptors were analysed through crystal structure analysis and docking simulations #Vornorexant #OrexinReceptors #CrystalStructure doi.org/10.1107/S205...

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Structural Biology Communications @actacrystf.iucr.org · 08/07/2026

This structure of macrophage migration inhibitory factor is a contribution to our cross-journal Early Career Scientists in Structural Science special issue. Find out more at journals.iucr.org/early-career... #SSGCID #MacrophageMigrationInhibitoryFactor doi.org/10.1107/S205...

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Structural Biology Communications @actacrystf.iucr.org · 07/07/2026

July issue is out now! journals.iucr.org/f/issues/202... This month's cover star is the type VI secretion system adaptor protein Tla3 from Pseudomonas aeruginosa strain UCBPPPA14. Find out more about this structure at doi.org/10.1107/S205...

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Structural Biology Communications @actacrystf.iucr.org · 16/06/2026

The structure of spectrin-like repeat 24 of human dystrophin is in excellent agreement with the AlphaFold model, supporting AlphaFold modeling of all 24 dystrophin spectrin-like repeats #Dystrophin #SpectrinLikeRepeat #DuchenneMuscularDystrophy doi.org/10.1107/S205...

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Structural Biology Communications @actacrystf.iucr.org · 11/06/2026

The structure of a complex between human RAGE ectodomain and S100A6 variant Y84C provides a possible model for S100 covalent homodimerization that is fully compatible with RAGE binding #S100Proteins #Cysteines #CovalentHomodimerization doi.org/10.1107/S205...

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Structural Biology Communications @actacrystf.iucr.org · 10/06/2026

The first structure of a cold-active arginase reveals a modest reduction in structural rigidity associated with cold adaptation #ColdActiveEnzymes #Arginases #XRayCrystallography doi.org/10.1107/S205...

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Structural Biology Communications @actacrystf.iucr.org · 09/06/2026

Acetylation-mimicking K214Q and K216Q variant structures of Escherichia coli glucokinase showed that acetylation mimics impaired activity and produced domain shifts #Glucokinases #LysineAcetylation #AcetylationMimickingMutations doi.org/10.1107/S205...

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Structural Biology Communications @actacrystf.iucr.org · 08/06/2026

Structural and enzymatic characterization of an Asp49 phospolipase A2 (PLA2) from Lachesis muta expands our understanding of structure–function relationships among viperid PLA2s #SnakeVenomPhospholipaseA2 #LachesisMuta #ProteinOligomer doi.org/10.1107/S205...

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Structural Biology Communications @actacrystf.iucr.org · 02/06/2026

The June issue is out! journals.iucr.org/f/issues/202... The cover illustration - Plasmodium vivax macrophage migration inhibitory factor - is from an article forming part of our Early Career Scientists in Structural Science special issue. Find out more and submit: journals.iucr.org/early-career...

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Structural Biology Communications @actacrystf.iucr.org · 06/05/2026

New issue is out! journals.iucr.org/f/issues/202... On the cover: the atomic structure of human dystrophin spectrin-like repeat 24 determined at 2.14 Å resolution journals.iucr.org/f/issues/202...

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Structural Biology Communications @actacrystf.iucr.org · 23/04/2026

Modifying the bacterial strain led to cleaner bacterial expression of a synthetic BRIL antibody that facilitates protein structure determination via both crystallography and cryo-EM #CryoEM #XRayCrystallography #BRIL doi.org/10.1107/S205...

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Structural Biology Communications @actacrystf.iucr.org · 22/04/2026

High-resolution structures of α-bCA2 with sulfonamide derivatives provides experimentally supported information defining their binding mode and supporting inhibitor optimization #CarbonicAnhydraseII #SulfonamideInhibitors #XRayCrystallography doi.org/10.1107/S205...

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Structural Biology Communications @actacrystf.iucr.org · 21/04/2026

An acylated GLP-1/GIP analogue peptide forms a uniquely porous spiral crystal structure composed of clockwise-ascending monomers in a square pattern #GLP1 #Peptides #Crystallization doi.org/10.1107/S205...

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Structural Biology Communications @actacrystf.iucr.org · 20/04/2026

A comprehensive survey catalogues all pentatricopeptide repeat protein crystal structures, analysing their crystallographic properties, structural features and contributions to understanding function #PentatricopeptideRepeatProteins #RNARecognition doi.org/10.1107/S205...

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Structural Biology Communications @actacrystf.iucr.org · 08/04/2026

Our April issue is out now! journals.iucr.org/f/issues/202... Crystallization was investigated as a preparative strategy for a GLP-1/GIP lipopeptide and led to what is believed to be the first reported crystal structure of an unbound GLP-1/GIP analogue doi.org/10.1107/S205...

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Structural Biology Communications @actacrystf.iucr.org · 19/03/2026

The structure of endo-β-N-acetylglucosaminidase was determined at 1.8 Å resolution, revealing a unique spatial arrangement of domain IV, which is suggested to contribute to substrate recognition #EndoNAcetylglucosaminidases #GH85 #ComplexNGlycans doi.org/10.1107/S205...

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Structural Biology Communications @actacrystf.iucr.org · 18/03/2026

The structure of a chimeric efflux pump was determined by cryoEM under apo and kanamycin-supplemented conditions and adopted symmetric-like and asymmetric conformations #PseudomonasAeruginosa #DrugEffluxTransporters #MembraneProteins doi.org/10.1107/S205...

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Structural Biology Communications @actacrystf.iucr.org · 17/03/2026

MBP fusion is an effective and generalizable approach to enable crystallographic studies of engineered binding proteins that are otherwise difficult to crystallize #Monobody #Aggregation #MaltoseBindingProtein doi.org/10.1107/S205...

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Structural Biology Communications @actacrystf.iucr.org · 16/03/2026

This report of the structure of a carbon-nitrogen hydrolase doi.org/10.1107/S205... is the first contribution to the Early Career Scientists in Structural Science special issue! Find out more, join in and submit at journals.iucr.org/early-career...

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Structural Biology Communications @actacrystf.iucr.org · 09/03/2026

Here's our March issue: journals.iucr.org/f/issues/202... On the cover: the structure of the chimeric RND-type multidrug-efflux pump protein MexBYB was determined by cryoEM under apo and kanamycin-supplemented conditions journals.iucr.org/f/issues/202...

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Structural Biology Communications @actacrystf.iucr.org · 19/02/2026

This structure of a tRNA acceptor-stem mimic demonstrates the use of bromine and phosphorus anomalous scattering for RNA structure determination #Crystallography #AnomalousScattering #NucleicAcids doi.org/10.1107/S205...

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Structural Biology Communications @actacrystf.iucr.org · 18/02/2026

Sample preparation from α- and β-crustacyanin pigments purified from ex vivo material from the American lobster Homarus americanus for X-ray crystallography and cryo-electron microscopy studies #Astaxanthin #Crustacyanin #Absorption doi.org/10.1107/S205...

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Structural Biology Communications @actacrystf.iucr.org · 17/02/2026

The highest resolution DNA-free TaXPD structure to date uniquely resolves loop 510–514 in the long-form, DNA-free TaXPD model #XRayCrystallography #Helicases #Archaea doi.org/10.1107/S205...

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Structural Biology Communications @actacrystf.iucr.org · 16/02/2026

Potential 14-3-3 binding sites in sirtuins were identfied and the interactions of peptides representing phosphorylation sites in sirtuin 3 and sirtuin 1 with 14-3-3 proteins were characterized #Sirtuin #Phosphopeptides #Regulation doi.org/10.1107/S205...

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Structural Biology Communications @actacrystf.iucr.org · 12/02/2026

The flexible loop in Methanococcus jannaschii dihydroorotase with substrate bound adopts both the loop-out and loop-in conformations #Dihydroorotase #MethanococcusJannaschii #PyrimidineBiosynthesis doi.org/10.1107/S205...

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Structural Biology Communications @actacrystf.iucr.org · 11/02/2026

The crystal structure of the class IIIb chitinase from Crocus vernus is reported, together with in silico analyses of inhibitor interactions and antifungal and chitinase assays #CrocusVernus #Chitinase #TIM doi.org/10.1107/S205...

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Structural Biology Communications @actacrystf.iucr.org · 10/02/2026

Single surface substitutions can mprove the crystallizability and diffraction properties of a flexible two-domain protein even if they increase the entropy of the residue #MultidomainProtein #PointMutation #ProteinCrystallization doi.org/10.1107/S205...

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Structural Biology Communications @actacrystf.iucr.org · 09/02/2026

What are the effects of the presence of polyethylene glycol in macromolecular crystals? #PolyethyleneGlycol #Mechanism #Crystallization doi.org/10.1107/S205...

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Structural Biology Communications @actacrystf.iucr.org · 04/02/2026

February issue now available: journals.iucr.org/f/issues/202... The cover shows the crystal structure of an RNA complex composed of four strands determined by the complementary use of bromine and phosphorus anomalous signals. Find out more at doi.org/10.1107/S205...

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Structural Biology Communications @actacrystf.iucr.org · 05/01/2026

First issue of 2026 is out: journals.iucr.org/f/issues/202... On the cover: single surface substitutions improve the crystallizability and diffraction properties of a flexible two-domain protein, even if they increase the entropy of the respective residue. Read more at doi.org/10.1107/S205...

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Structural Biology Communications @actacrystf.iucr.org · 18/12/2025

CryoSift is a platform-independent convolutional neural network tool for assessing the quality of 2D averages to enable the automatic selection of suitable particles for high-resolution reconstructions #Automation #DataProcessing #CryoEM doi.org/10.1107/S205...

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Structural Biology Communications @actacrystf.iucr.org · 17/12/2025

The rigid single-domain structure and reproducible crystallization behavior of PF1765 from P. furiosus indicate potential use as a fusion domain to aid the crystallization of membrane proteins or complexes #PF1765 #UPF0235 #ProteinCrystallography doi.org/10.1107/S205...

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Structural Biology Communications @actacrystf.iucr.org · 16/12/2025

Structural analysis of apo and UDP-bound tetrahydrobiopterin glucosyltransferase revealed features at the active-site pocket differing from other retaining GT-B glycosyltransferases #Tetrahydrobiopterin #GTBGlycosyltransferase #Crystallography doi.org/10.1107/S205...

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Structural Biology Communications @actacrystf.iucr.org · 15/12/2025

In the coenzyme-bound structure of short-chain dehydrogenase from Brucella ovis, two different orientations of the NAD+ coenzyme are fortuitously observed #ShortChainDehydrogenaseReductase #ResearchExperienceForUndergraduates doi.org/10.1107/S205...

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Structural Biology Communications @actacrystf.iucr.org · 03/12/2025

Our last issue of 2026 is available: journals.iucr.org/f/issues/202... On the cover: two different orientations of the NAD coenzyme are fortuitously observed in the NAD+-bound structure of a short-chain dehydrogenase from Brucella ovis. Find out more at doi.org/10.1107/S205...

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