iiinova — where your digital self keeps evolving

Abhi Aggarwal

@abhiaggarwal.bsky.social

1.1K followers 1.7K following 11 posts

Posts Replies Media

Abhi Aggarwal @abhiaggarwal.bsky.social · 22/06/2026

🟧 Orange is the new green?? 🟧 New sensitive orange calcium indicator (🟠OCaMP) now out in Nature Comms: www.nature.com/articles/s41... Highlights ⚡ Detects single action potentials in vivo 🔬 Optimized for 1030 nm imaging 📸 Highly photostable, minimal photoswitching 🌈 Multiplex with green biosensors

0309

Reposted by Abhi Aggarwal

allen institute @alleninstitute.org · 23/12/2025

Glutamate is the primary molecule that neurons use to communicate with each other. Previously, scientists have mostly recorded when neurons fire output signals, but now with a new glutamate indicator, they can record the many inputs that causes cells to fire. 🧵 #neuroskyence

682268371

Abhi Aggarwal @abhiaggarwal.bsky.social · 23/12/2025

iGluSnFR4 is now available @natmethods.nature.com www.nature.com/articles/s41... Glutamate indicators with increased sensitivity and tailored deactivation rates 🧪

nature.com

Glutamate indicators with increased sensitivity and tailored deactivation rates - Nature Methods

iGluSnFR4f and iGluSnFR4s are the latest generation of genetically encoded glutamate sensors. They are advantageous for detecting rapid dynamics and large population activity, respectively, as demonst...

03917

Abhi Aggarwal @abhiaggarwal.bsky.social · 25/03/2025

🚨iGluSnFR4 is finally out!🚨🧪 We present iGluSnFR4f and 4s, a novel pair of genetically-encoded glutamate indicators designed for high-fidelity imaging of synaptic activity in the living brain. ⬇️ www.biorxiv.org/content/10.1... 🎥 Below: iGluSnFR4s detecting minis in cultures w/ TTX #Neuroscience

717159

Reposted by Abhi Aggarwal

Wonder of Science @wonderofscience.bsky.social · 01/02/2025

High-speed video showing glutamate lighting up as it’s released in synapses, visualizing the neurotransmitters of the brain with the fluorescent indicator protein iGluSnFR3. Credit: Allen Institute, Aggarwal et al.

319528

Abhi Aggarwal @abhiaggarwal.bsky.social · 12/11/2024

First sky post 🦋 Sharing some vibrant iGluSnFR3 minis in cultured neurons!

2839