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Joanna Achinger

@aachinger.bsky.social

613 followers 550 following 7 posts

Lab head in 3D chromatin organisation at SAiGENCI, University of Adelaide 🇦🇺 | Interested in 3D chromatin structure, gene regulation, transposable elements and cancer | website: achingerlab.com

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Joanna Achinger @aachinger.bsky.social · 23/12/2024

This study, led by Elyssa Campbell with contributions from Fa Valdes Mora, Tim Peters, Amanda Khoury, Geri Laven-Law and Theresa Hickey reveals how chromatin environment modulates AR binding to establish the AR-mediated transcriptional program. (5)

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Joanna Achinger @aachinger.bsky.social · 23/12/2024

We studied TF binding, 3D chromatin interactions and nascent transcription during androgen stimulation time-course in prostate cancer cells (LNCaP). We found that AR rapidly binds to FOXA1 pre-marked sites and induces nascent transcription. H3K27ac is often deposited prior to AR binding. (2)

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