iiinova — where your digital self keeps evolving

Alexander Dietrich

@a-dietrich.bsky.social

Reposted by Alexander Dietrich

Judith Bernett @judith-bernett.bsky.social · 03/06/2025

🧬🖥️So excited to show you the outcome of @pascivers.bsky.social and my latest project: "From Hype to Health Check: Critical Evaluation of Drug Response Prediction Models with DrEval" doi.org/10.1101/2025.05.26.655288, published with M. Picciani, M. Wilhelm, K. Baum & @itisalist.bsky.social. 🧵1/10

Overview of the DrEval framework. Via input options, implemented state-of-the-art models can be compared against baselines of varying complexity. We address obstacles to progress in the field at each point in our pipeline: Our framework is available on PyPI and nf-core and we follow FAIReR standards for optimal reproducibility. DrEval is easily extendable as demonstrated here with a pseudocode implementation of a proteomics-based random forest. Custom viability data can be preprocessed with CurveCurator, leading to more consistent data and metrics. DrEval supports five widely used datasets with application-aware train/test splits that enable detecting weak generalization. Models are free to use provided or custom cell line– and drug features. The pipeline supports randomization-based ablation studies and performs robust hyperparameter tuning for all models. Evaluation is conducted using meaningful, bias-resistant metrics to avoid inflated results from artifacts such as Simpson’s paradox. All results are compiled into an interactive HTML report. Created in https://BioRender.com.

1163

Reposted by Alexander Dietrich

DaiSyBio @daisybio.de · 03/04/2025

Weihenstephan Bioinformatics Symposium 2025: More than 75 scientists from Bavaria and the world came together to share talks and create new synergies. It was great to host this event, for those who missed it: The next edition is planned for 2027 😉

182