U of G researchers are using CRISPR interference to spot genetic vulnerabilities in Candida albicans, a leading cause of life-threatening infections.

Nature Microbiology, Published online: 11 May 2026; doi:10.1038/s41564-026-02356-wThis study presents a pooled CRISPRi screening approach in Candida albicans to investigate essential genes at scale, revealing environment- and strain-dependent gene sensitivities and conserved vulnerabilities relevant to antifungal drug discovery.

This study presents a pooled CRISPRi screening approach in Candida albicans to investigate essential genes at scale, revealing environment- and strain-dependent gene sensitivities and conserved vulner...