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RPTH @rpth.bsky.social · 13/09/2025

Intestinal transplantation can have complex hemostatic complications. This study of 145 transplants reports bleeding (38%) and thrombosis (26%) in their patient cohort. Read more here to learn about the risks and management! www.rpthjournal.org/article/S247...

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RPTH @rpth.bsky.social · 11/09/2025

Combined oral contraception (COC) alters hemostasis in ways standard labs may underestimate. Thrombin generation assays with anti-PS and anti-TFPI antibodies revealed a marked reduction in anticoagulant activity after just 3 months of COC use. www.rpthjournal.org/article/S247...

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RPTH @rpth.bsky.social · 31/07/2025

Gynecological and obstetric complications in women with congenital fibrinogen deficiencies: In qualitative fibrinogen deficiencies, the rates of live birth, postpartum hemorrhage, and miscarriage were 58%, 47%, and 42%, respectively. See the details here: www.rpthjournal.org/article/S247...

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RPTH @rpth.bsky.social · 30/07/2025

This excellent commentary from Tzu-Fei Wang discusses a recent study about bleeding risk after a fall in people taking anticoagulants for atrial fibrillation.🩸 Commentary: www.rpthjournal.org/article/S247... Article: www.rpthjournal.org/article/S247...

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RPTH @rpth.bsky.social · 29/07/2025

New insight into thrombotic mechanisms of SARS-CoV2 infection? Using drosophila genetic screening, Quan Zhang and team identified orf7a as a trigger for endothelial activation and release of von Willebrand factor, and may result in thrombosis. www.rpthjournal.org/article/S247...

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RPTH @rpth.bsky.social · 28/07/2025

Acetaldehyde is a pollutant found in tobacco and eCig smoke, cosmetic products, and the product of alcohol metabolism. And did you know it can affect fibrin structure? Read more about the effect of this common toxicant on the fibrinolytic system! www.rpthjournal.org/article/S247...

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RPTH @rpth.bsky.social · 27/07/2025

New study from Steven Humphreys reveals that arterial and venous endothelial cells elongate and remodel differentially in response to flow rate. Arterial endothelial cells are more responsive to inflammation and significantly delay clot breakdown. More here: www.rpthjournal.org/article/S247...

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RPTH @rpth.bsky.social · 26/07/2025

A small panel of VWF variants were investigated for expression and function - and how they might cause Von Willebrand Disease. Golzar Mobayen and team reveal that the D4 and C-domains of VWF might play a role! 📖 www.sciencedirect.com/science/arti...

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RPTH @rpth.bsky.social · 25/07/2025

Hanqiang Deng provides excellent commentary on an outstanding article about heterogeneous responses to shear stress in different endothelial cell subtypes. Commentary here: www.rpthjournal.org/article/S247... Original Article by Allaura Cox and Christopher Ng: www.rpthjournal.org/article/S247...

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RPTH @rpth.bsky.social · 24/07/2025

This study from Eva Kempers and team examined menstrual blood loss and related quality of life among women on antiplatelet therapy and a control group. Their data reveal that both outcomes were comparable, great news for women who need antiplatelet therapy. www.rpthjournal.org/article/S247...

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RPTH @rpth.bsky.social · 23/07/2025

This new study investigates adenoviral vector vaccine-associated thrombosis/thrombocytopenia risk. ✅ Adenoviral vectors can infect megakaryocytes ✅ Concurrent infection may increase chemokine receptor expression Check out the results here: www.rpthjournal.org/article/S247...

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RPTH @rpth.bsky.social · 18/07/2025

Current ICD codes make it difficult to track venous thrombosis incidence in real time. This original article suggests use of "I26" which has high specificity for VTE in the Unite States, and may help capture the incidence of PE. 💻 read more about it here www.rpthjournal.org/article/S247...

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RPTH @rpth.bsky.social · 17/07/2025

How do different anti-FXa activity assays stack up when measuring plasma levels of DOAC? The PAUSE study reveals that although there is variability, it is not clinically relevant. 📊 Read more about the study and results here: www.rpthjournal.org/article/S247...

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RPTH @rpth.bsky.social · 15/07/2025

Great news for patient care! This study investigated if anticoagulation in A Fib patients increases bleeding risk in recurrent fallers. Fortunately , no association with major bleeding was found! www.rpthjournal.org/article/S247...

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RPTH @rpth.bsky.social · 14/07/2025

This study from Thor-David Halstensen and team externally validated the new DAYS score for predicting DVT . 📊 Read more to find out how it stacks up compared to other risk prediction scores www.rpthjournal.org/article/S247...

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RPTH @rpth.bsky.social · 13/07/2025

❤️‍🔥 Thrombosis risk after an acute myocardial infarction This retrospective study reveals that lack of revascularization may be associated with higher mortality in those who have a LV thrombus. 📖 www.rpthjournal.org/article/S247...

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RPTH @rpth.bsky.social · 12/07/2025

How about a double feature for a weekend read? ☕ This commentary "Tougher clots, safer lives?" by Zsuzsa Bagoly discusses a recent paper from @valtutwiler.bsky.social. Commentary: www.rpthjournal.org/article/S247... Original Paper: www.rpthjournal.org/article/S247...

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RPTH @rpth.bsky.social · 10/07/2025

Maternal antiphospholipid antibodies can cross the placental barrier to neonates - but does this increase risk of neonatal thrombosis? 🤰 This case report describes the first known neonatal intracardiac thrombosis - www.rpthjournal.org/article/S247...

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RPTH @rpth.bsky.social · 09/07/2025

This team studied the effects of prothrombotic single nucleotide polymorphisms on VTE risk during atrial fibrillation. ✅ Factor V Leiden was associated with risk of VTE during A Fib. ⛔ The 5-SNP genetic risk score was not associated with VTE risk during A Fib. www.rpthjournal.org/article/S247...

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RPTH @rpth.bsky.social · 19/06/2025

Fabulous commentary from Julie Jaffray, discussing if BMI influences recovery from pediatric venous thrombosis. www.rpthjournal.org/article/S247... Original Article Here: www.rpthjournal.org/article/S247...

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RPTH @rpth.bsky.social · 18/06/2025

What happens to platelets during recovery from trauma? New study from Andrea Rossetto and team demonstrates that prolonged thrombocytopenia is associated with higher rates of organ dysfunction and need for support. www.rpthjournal.org/article/S247...

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RPTH @rpth.bsky.social · 13/06/2025

🧪 A novel quantitative assay to evaluate fibrinolysis! Robert Medcalf and team share the Halo Fluorescence Fibrinolysis (HoFF) test in this new Methodological Article. www.rpthjournal.org/article/S247... 😇

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RPTH @rpth.bsky.social · 03/06/2025

🚑 Trauma-induced coagulopathy leads to depletion of clotting factors, like FV. This study from Pieter H Sloos and team looks at the impact of reduced FV activity on outcomes in trauma patients. www.rpthjournal.org/article/S247...

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RPTH @rpth.bsky.social · 02/06/2025

Exploring clot structure and stability 🩸 Biomechanical studies from @valtutwiler.bsky.social shows that FXIIIa crosslinking increases clot toughness and strength 💪 www.rpthjournal.org/article/S247...

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RPTH @rpth.bsky.social · 23/05/2025

New study protocol from PRONOSPECT! Study recommends use of SPECT/CT to visualize residual pulmonary vascular obstruction after pulmonary embolism as a prediction tool for recurrence. www.rpthjournal.org/article/S247... #pulmonaryembolism

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RPTH @rpth.bsky.social · 21/05/2025

Anti-FXIa anticoagulants carry low bleeding risk but we lack guidelines on managing that risk in invasive procedures. Read this excellent literature review from French Working Group on Perioperative Hemostasis that proposes guidelines to optimize patient safety. www.rpthjournal.org/article/S247...

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RPTH @rpth.bsky.social · 20/05/2025

🚨 SCAM ALERT: If you get a message saying your paper was “provisionally selected for a Best Researcher Award” or a similar message with a link—don’t click it! These phishing scams target researchers. Stay safe and verify before you respond!

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RPTH @rpth.bsky.social · 16/05/2025

🧪 DOACs for thromboprophylaxis in multiple myeloma? This review from Catalina Codreanu demonstrates that evidence is limited, outcomes inconsistent, and study quality moderate at best. VTE risk remains high and well-designed trials urgently needed. Full review 👉 www.rpthjournal.org/article/S247...

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RPTH @rpth.bsky.social · 15/05/2025

🧬 High-risk #thrombophilia has similar prevalence in provoked and unprovoked VTE—challenging assumptions behind selective testing. Most common in pregnancy-related morbidity. Clinical + lab markers can guide smarter testing. www.rpthjournal.org/article/S247... @Kristina Vrotniakaite-Bajerciene

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RPTH @rpth.bsky.social · 13/05/2025

RPTH is looking for an Associate Editor with expertise in epidemiology + clinical thrombosis to join our editorial team! 🕒 2–3 hrs/week 💰 Honorarium included 🌍 Help shape the future of research ▶️Must be an @isth.org member Apply now: bit.ly/4j05k22

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RPTH @rpth.bsky.social · 11/05/2025

Hormonal changes during perimenopause can lead to a variety of symptoms - how best to manage while considering #thrombosis risk? 🤷‍♀️ This excellent State-of-the-Art review by by Briony A. Cutts and Kristy Fennessy offers insight into this clinical scenario. www.rpthjournal.org/article/S247...

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RPTH @rpth.bsky.social · 09/05/2025

Vitamin K Deficiency is common in children with cholestatic liver disease. This excellent meta-analysis and review provides updates on the best way to supplement with Vitamin K. www.rpthjournal.org/article/S247... #bleeding #hemostasis

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RPTH @rpth.bsky.social · 07/05/2025

Does body composition influence responses to dexamethasone in cases of ITP? 🩸 Check out this report from Tyler Everhardt and team on platelet levels following Dexamethasone treatment: www.rpthjournal.org/article/S247...

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RPTH @rpth.bsky.social · 06/05/2025

Physician-patient communication is key to improving outcomes in healthcare. But, more research is needed to determine the best way to communicate a diagnosis of acute venous thrombosis to patients. Let's work together to figure it out! www.rpthjournal.org/article/S247...

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RPTH @rpth.bsky.social · 05/05/2025

🏃‍♂️ 🏋️ Does exercise help with recovery after a pulmonary embolism? This study from Norway shows that 8 weeks of exercise reduced dyspnea and improved quality of life up to 6 months after a PE. Check it out! www.rpthjournal.org/article/S247...

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RPTH @rpth.bsky.social · 04/05/2025

Desmopressin is a great therapeutic option for VWD and Hemophilia A, 🩸 but how do we know it will work? This proteomic study found that patient levels of VWF predict who responds to desmopressin. Read about it here: www.rpthjournal.org/article/S247...

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RPTH @rpth.bsky.social · 03/05/2025

How do you classify and diagnose antiphospholipid syndrome? The American College of Rheumatology recently published a classification system. Will this help with diagnosis and treatment? Read this Forum article to get the full story. www.rpthjournal.org/article/S247...

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RPTH @rpth.bsky.social · 02/05/2025

Pediatric VTE carries a lot of risk - is weight gain one of them? This study from Mary Dang shows that BMI does increase after VTE - indicating that healthy lifestyle changes should be encouraged in these patients. www.rpthjournal.org/article/S247...

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RPTH @rpth.bsky.social · 30/04/2025

Immunothrombosis is a puzzle! 🧩 This review by Luisa Müller and team discusses why platelet factor 4 might be a key piece to consider when immunothrombosis and thrombocytopenia are present. Check it out: www.rpthjournal.org/article/S247...

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RPTH @rpth.bsky.social · 19/04/2025

Settle in for a great weekend read! What do we know about lipid signatures in immunothrombosis? 🦠 Tamam Bakchoul and Madhumita Chatterjee fill us in on lessons learned from VITT. Check out their Commentary: www.rpthjournal.org/article/S247...

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RPTH @rpth.bsky.social · 18/04/2025

What are your thoughts on administering Factor IX after gene therapy for Hemophilia B? Quenton Van Thillo and Cedric Hermans weigh in on this in their new Forum Article! www.rpthjournal.org/article/S247... #hemophilia

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RPTH @rpth.bsky.social · 17/04/2025

Cancer associated DVT results in several clinical outcomes - but can we predict which ones? 🤔 Findings from the ONCO-DVT Study: Patients with symptomatic DVT had higher risk of recurrent VTE than patients who had asymptomatic DVT. Check out the data here: www.rpthjournal.org/article/S247...

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RPTH @rpth.bsky.social · 16/04/2025

How effective targeting FXIa in preventing DVT? Excellent new study from Oguri shows that FXI is present in clots, and targeting FXI with ONO-1600568 is as effective as rivaroxaban in reducing clot and fibrin deposition in a pre-clinical model. Check it out! www.rpthjournal.org/article/S247...

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RPTH @rpth.bsky.social · 13/04/2025

What can we learn from plasma proteomics? A mass spec-based study reveals vitamin K antagonist and disease-specific signatures, but no clear biomarkers for thromboembolic events. The challenge? Heterogeneity in patient profiles complicates risk stratification. www.rpthjournal.org/article/S247...

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RPTH @rpth.bsky.social · 11/04/2025

"Adeno-associated virus-based gene therapy for hemophilia–addressing the gaps." www.rpthjournal.org/article/S247... Another great read ahead of #worldhemophiliaday!

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RPTH @rpth.bsky.social · 11/04/2025

Hemophilia drug trials mostly occur in high-income countries, but lower-middle-income regions are seeing a slow rise in participation. 🌍 This global study raises questions about generalizability, ethics, and access to treatments for rare bleeding disorders. 👉 www.rpthjournal.org/article/S247...

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RPTH @rpth.bsky.social · 10/04/2025

🤔 "Can hemophilia be cured? It depends on the definition" 🩸 A thoughtful review on #hemophilia treatment options in the era of gene therapy. 🔗 Check it out here www.rpthjournal.org/article/S247... #WorldHemophiliaDay

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RPTH @rpth.bsky.social · 09/04/2025

"Gene therapy in hemophilia: the dawn of a new era" 🧬 🩸 Check out this excellent review on #hemophlilia treatment www.rpthjournal.org/article/S247... #worldhemophiliaday

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RPTH @rpth.bsky.social · 08/04/2025

This week we are highlighting some of the excellent research in #hemophilia and other #bleeding disorders published in RPTH Journal. Check out this fantastic Narrative Review on the best ways to initiate thrombin generation in hemophilia. www.rpthjournal.org/article/S247... #worldhemophiliaday

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RPTH @rpth.bsky.social · 08/04/2025

🩸In acquired hemophilia A, the first year post-remission is the danger zone. New study from Wolfgang Miesbach shows that initial FVIII <1 IU/dL and failure to reach complete remission = higher relapse risk. Monitor patients closely! 🔗 www.rpthjournal.org/article/S247... #worldhemophiliaday

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