2 things i hope don’t happen:
1. Millie miscarries
2. They don’t bother making Millie look pregnant when she gets to the later stages
#Hellaverse #HelluvaBoss #HelluvaBossSeason3
h0r53f7y.bsky.social
@h0r53f7y.bsky.social
517 followers 899 following 4.6K posts
38 she/he Chaotic neutral sh*t gremlin. Lucifer Morningstar’s emotional support fae. Minors DNI
![Summary
Small cell lung cancer (SCLC) is a highly aggressive neoplasm with limited sensitivity to anti-PD-(L)1 blockade, which is likely caused by the epigenetic silencing of MHC-I.
Elucidating MHC-I-independent immune recognition mechanisms is therefore crucial for enhancing treatment responses and improving clinical outcomes in a greater number of patients. Leveraging single-cell approaches, we discovered ys T cell infiltration in biospecimens from patients with SCLC.
Despite PD-1 expression, yô T cells maintained a cytotoxic transcriptional profile, suggesting an anti-tumor role. Indeed, high y T cell infiltration in two practice-changing clinical trials predicted improved response to anti-PD-L1 immunotherapy in patients with SCLC.
Moreover, using preclinical models, we demonstrated that ys T cells are effective at tarlatamab (delta-like ligand 3 [DLL3]-CD3 bispecific T cell engager [BiTE]) - redirected SCLC killing and that zoledronate, an FDA-approved compound, can sensitize SCLC cells to ys T cell-mediated killing.
Thus, our findings suggest that engaged yo T cells are potentially valuable targets for SCLC therapy.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:llgfbjvsqkaicezsf7mzjxr3/bafkreibpprzjvonklfdkvcysczoitp4gziaw3le3ei4jt2ngn256dfeiti)
