Engineering programmable tumor microenvironment interactions through single-cell bioprinting of spatially defined cell microarrays, Helms, Haylie R, Bertassoni, Luiz E

Engineering programmable tumor microenvironment interactions through single-cell bioprinting of spatially defined cell microarrays, Helms, Haylie R, Bertassoni, Luiz E

Tissue development and function are determined by the spatial organization of individual cells and their interactions. Yet experimental platforms capable of reconstructing cellular organization with s...

Tissue development and function are determined by the spatial organization of individual cells and their interactions. Yet experimental platforms capable of reconstructing cellular organization with s...

Gain-of-function (GOF) mutations in either Kir6.1 (encoded by KCNJ8) or SUR2 (encoded by ABCC9) are causally associated with Cantu syndrome (CS), characterized by coarse facial appearance, hypertricho...

This newly developed biological probes/proteomics method yields functional antibodies targeting previously undruggable targets.

Spatial transcriptomics is a powerful tool for investigating how cellular composition and spatial relationships influence cell behavior. Here, we pres…

Abstract. Engineered tumor avatars provide opportunities to identify mechanisms of cancer initiation, progression, and treatment resistance. We previously reported the development of a single-cell bio...

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We report that GABAA receptors in a patch-clamped biological cell form a short-term memory circuit when integrated with a scanning-probe microfluidic device. Laminar patterns of receptor activators (a...

G protein–coupled receptors (GPCRs) are biologic switches that transduce extracellular stimuli into intracellular responses in the cell. Temporally resolving GPCR transduction pathways is key to under...

G protein–coupled receptors (GPCRs) are biologic switches that transduce extracellular stimuli into intracellular responses in the cell. Temporally resolving GPCR transduction pathways is key to under...

Using structure- and ligand-based design principles, a novel series of piperidyl chromane arylsulfonamide Nav1.7 inhibitors was discovered. Early optimization focused on improvement of potency through...

Using structure- and ligand-based design principles, a novel series of piperidyl chromane arylsulfonamide Nav1.7 inhibitors was discovered. Early optimization focused on improvement of potency through...

Autonomous formation of primitive cell-like compartment populations is observed on thin sections of early Earth minerals and a Martian meteorite specimen. Multilamellar lipid reservoirs undergo a ser...

Autonomous formation of primitive cell-like compartment populations is observed on thin sections of early Earth minerals and a Martian meteorite specimen. Multilamellar lipid reservoirs undergo a ser...

Methods that can control and vary the solution environment around single cells are abundant. In contrast, methods that offer direct access to the intracellular proteome and genome in single cells with...

Methods that can control and vary the solution environment around single cells are abundant. In contrast, methods that offer direct access to the intracellular proteome and genome in single cells with...

Jové et al. characterize specialized blood-feeding sensory neurons in female Aedes aegypti mosquitoes and demonstrate that they encode the distinction between blood and floral nectar. Polymodal integr...

Jové et al. characterize specialized blood-feeding sensory neurons in female Aedes aegypti mosquitoes and demonstrate that they encode the distinction between blood and floral nectar. Polymodal integr...

Even though gain, loss, or modulation of ion channel function is implicated in many diseases, both rare and common, the development of new pharmaceuticals targeting this class has been disappointing, ...

Cellular compartments are membrane-enclosed, spatially distinct microenvironments that confine and protect biochemical reactions in the biological cell. On the early Earth, the autonomous formation of...

Given the importance of ion gradients and fluxes in biology, monitoring ions locally at the exterior of the plasma membrane of intact cells in a noninvasive manner is highly desirable but challenging....

Scientific Reports - 3D micro-organisation printing of mammalian cells to generate biological tissues