Chris Ashwood @cashwood.proteaglyco.com · 18/07/2025As an occasional #teamMannose, is mannose not as well described in this area? I would’ve thought that there would be a mannose degradation pathway here. 100
Lucy Crouch @lucyicm.bsky.social · 18/07/2025Hi Chris, for B.bifidum I can't see any putative high-mannose breakdown CAZymes, but other species do have these. There has been a characterisation in B. longum. www.nature.com/articles/s41...nature.comMechanism of high-mannose N-glycan breakdown and metabolism by Bifidobacterium longum - Nature Chemical BiologyThe human gut Bifidobacterium longum can use host N-glycans as carbon and energy sources via a specific and cooperative multienzymatic system. 110
Chris Ashwood @cashwood.proteaglyco.com · 18/07/2025Interesting, maybe emphasises their commensal nature. Thanks Lucy! 010
