Very glad to contribute to this collaboration exploring the role of truncated proteins produced by Influenza DelVG during infection.
@asherleeks.bsky.socialVery exciting finding: most viruses produce large deletion mutants (DVGs), some of which can spread as cheats. In flu, DVGs often delete > 80% of the genome, so we typically assume they don't encode functional proteins...
doi.org/10.1093/nar/...
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doi.org
Cryptic proteins translated from deletion-containing viral genomes dramatically expand the influenza virus proteome
Abstract. Productive infections by RNA viruses require faithful replication of the entire genome. Yet many RNA viruses also produce deletion-containing viral ge