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Ewan St. John Smith @psalmotoxin.bsky.social · 10/02/2024

How does mechanosensation work? Nerves are critical, but recent work from Gary Lewin, Patrik Ernfors et al (nature.com/articles/s41...) builds on findings a few years ago that Schwann cells are involved in nociception (science.org/doi/10.1126/...) #neuroscience #touch #pain 🧪

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Ewan St. John Smith @psalmotoxin.bsky.social · 10/02/2024

Optogenetic stimulation of nociceptive Sox10+ Schwann cells activates diverse mechanoreceptors. Optogenetic inhibition of nociceptive Sox10+ Schwann cells inhibits diverse mechanoreceptors.

Fig. 1 | Nociceptive Sox10+ Schwann cells are required for nociceptor mechanosensitivity. a Schematic diagram of ex vivo preparation used to stimulate nociceptive Schwann cells with light. b, c Example traces of nociceptor types recorded. b Activity was recorded after blue light stimulation. c Spiking of the same nociceptor as in b to mechanical ramp and hold stimulation (10 s). d Proportion of nociceptors responding to blue light. e Latency of response to blue light compared to mechanical ramp and hold stimuli (AMs n = 12, C-M n = 9, C-polymodal n = 11) *P = 0.015, ***P = 0.0052, Mann–Whitney two tailed U-test. f–h Mean time course of nociceptor activation (1 s bins, 10 s, 250 mN amplitude ramp and hold stimulus), A- Mechano-nociceptors (AM n = 12) (f), C-mechano-nociceptors (C-M n = 9) (g), and polymodal C-fibers with thermal and mechanosensitivity (n = 11) (h). Mean spiking rates of the same receptors to blue light (blue) and mechanical stimuli (gray). ****P < 0.001 two-way ANOVA. i

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Dani cRabaiotti 🦀 @danirabaiotti.bsky.social · 11/02/2024

Hi Ewan, just a reminder that as per our rules all images in the feed should have alt text to enable people using screen readers to engage :) Especially at the moment it's super important as the alt text bot is struggling

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