Andrew Marderstein @amarderstein.bsky.social · 15/06/202615/ The paired RNA-seq also helped interpret FLARE variants. For example, two SNPs are only 78 bp apart but affect different genes: - one breaks an NFIL3 motif (lowering SENP3), - the other creates a ZEB/SNAI repressor motif (lowering TNFSF13). 100
Andrew Marderstein @amarderstein.bsky.social · 15/06/202616/ Finally, FLARE informed common variant architecture. As a schizophrenia heritability annotation in S-LDSC, FLARE-fetal brain beat the strongest region-based annotations. 100
Andrew Marderstein @amarderstein.bsky.social · 15/06/202617/ We're excited to share FLARE, >3 billion variant effect predictions across 132 adult and fetal brain and heart contexts, and all associated code and resources with the community. 100
