So excited to share our new work led by my awesome PhD student Hyland Gonzalez. She shows transcriptional effects of CYP2E1 deletion in alcohol naive mice and then goes on to show that mice lacking CYP2E1 drink more at baseline and escalate their drinking more after CIE compared to WT mice. 🍸🐁
@hylandgonzalez.bsky.socialCheck out my new paper on how Cyp2e1 deletion results in increased sensitivity to ethanol-induced motor impairment and increased drinking escalation in a CIE model:
doi.org/10.1111/acer...
doi.org
Cyp2e1 deletion in mice increases sensitivity to ethanol‐induced motor impairment and escalation of drinking behavior in the chronic intermittent ethanol model
This study investigates the impact of global Cyp2e1 knockout and wild-type mice to explore the effect of altered ethanol metabolism on behavior and gene expression. Knockout mice demonstrated altered...