Abraham lab at Harvard Medical School @abrahamlabhms.bsky.social · 16/09/2026We further determined a structure of the primase-polymerase core complex in a state that likely occurs during the synthesis of RNA primers. 100
Abraham lab at Harvard Medical School @abrahamlabhms.bsky.social · 16/09/2026Taken together, our work provides a mechanism for MPXV replisome assembly and E5 helicase-primase activation in viral DNA replication. These findings may provide valuable targets for antiviral therapy development that may lock 🔒 the replisome in conformational intermediates. 100
Abraham lab at Harvard Medical School @abrahamlabhms.bsky.social · 16/09/2026We would like to thank our collaborators @joeloparo.bsky.social lab and the Kranzusch lab at @danafarber.bsky.social and all others! 100
