Abraham lab at Harvard Medical School @abrahamlabhms.bsky.social · 16/09/2026Monkeypox virus (MPXV) has caused a global outbreak involving almost two hundred thousand cases since 2022. Though there is a vaccine, there are no reliable antivirals. 100
Abraham lab at Harvard Medical School @abrahamlabhms.bsky.social · 16/09/2026Viral helicase-primases and polymerases are important drug targets for DNA viruses; this motivated us to study these MPXV proteins. 100
Abraham lab at Harvard Medical School @abrahamlabhms.bsky.social · 16/09/2026We determined high-resolution cryo-EM structures of the MPXV hexameric E5 helicase-primase bound to the polymerase complex bound to DNA 🧬. The structures capture both of these key viral proteins in action. 100
