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Nils Kroemer @nbkroemer.bsky.social · 11/09/2024

Can we use macronutrients to understand altered food reward in depression? Our new preprint shows that patients with MDD report lower wanting & liking for foods rich in fat or protein (vs. carbs). #neuroscience 🩺 W/ @corcerebrum.bsky.social @neuromadlab.bsky.social www.medrxiv.org/content/10.1...

Altered food liking in depression is driven by macronutrient composition of the depicted food. We analyzed wanting and liking ratings of patients with major depressive disorder (MDD) and matched healthy control participants. Patients with MDD reported lower food wanting, whereas food liking was primarily associated with symptoms of anhedonia. We then evaluated whether the macronutrient composition of the food accounted for differences in ratings. This led to a substantial improvement in models and showed that patients with MDD show specific deficits for food rich in fat and protein.

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