As my #NewPI journey is starting I re-share my latest publication: 👉We uncovered a #phosphate #metabolite sensor, binding and regulating the #autophagy Atg1/ULK1 initiation complex to regulate #pexophagy in response to
phosphate availability. nature.com/articles/s41556-024-01348-4
nature.com
A metabolite sensor subunit of the Atg1/ULK complex regulates selective autophagy - Nature Cell Biology
Gross et al. show that Atg13 and Atg17 are dispensable for pexophagy during phosphate starvation in yeast. Instead, the metabolite sensor Pho81 binds the Atg1 kinase complex via Atg11 to promote Atg11...