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CJKHD @cjkhd.bsky.social · 28/01/2026

A #casereport and #literaturereview of renal cortical necrosis due to antiphospholipid syndrome. 🔬 #biopsy #necrosis #AKI @unityhealthto.bsky.social @csnscn.bsky.social doi.org/10.1177/2054...

Kidney biopsy findings at initial diagnosis of thrombotic microangiopathy (A, B) and postoperative renal cortical necrosis (C, D, E). Initial kidney biopsy reflecting thrombotic microangiopathy: (A) Glomerulus showing features of acute thrombotic microangiopathy: dilated capillary loops, mesangiolysis (white star) and fibrin thrombus (white arrow). In addition, periglomerular fibrosis due to chronic hypoperfusion. PAS 40×. (B) Ultrastructural features of chronic microangiopathy: subendothelial widening by fluffy proteinaceous material separating the endothelial cell from the GBM (white star) and forming double contours (white arrow). Endothelial cell hypertrophy (orange star) (TEM 20000×). Postoperative kidney biopsy: (C) Extensive necrosis (coagulative) with interstitial hemorrhage (white arrows). (H&E 20×). (D) Coagulative necrosis, interstitial inflammation (white arrows) in areas of reperfusion (H&E, 20×). (E) Extensive cortical necrosis (H&E 4×).