ME/CFS Science @mecfsscience.org · 18/09/20265) That was the case for 7 signals, but as the results in Table 1 show, no signal was present in all three cohorts. 4 could be tested in DecodeME, and none had a p-value close to significance. So the replication was quite limited. 170
ME/CFS Science @mecfsscience.org · 18/09/20266) The most interesting result was on chromosome 13 because it matched with expression of the gene CLYBL in the brain region called the putamen (part of the basal ganglia). CLYBL encodes a mitochondrial enzyme and is involved in vitamin B12 metabolism. 192
ME/CFS Science @mecfsscience.org · 18/09/20267) My personal interpretation is that the sample sizes for these cohorts are too small and that the findings may mostly reflect noise or confounding. The results are much more uncertain, IMHO than those from DecodeME. More comments and analysis here:s4me.infoPreprint - Seven replicated genomic associations of myalgic encephalomyelitis/chronic fatigue syndrome: a biobank study, 2026, Slaughter, Ponting et al. | Page 2 | Science for MEI see it as a positive that this work was done and published. We know previous work on UK biobank data only identified one variant for females. It seems to... 1111
