ME/CFS Science @mecfsscience.org · 17/09/20265) You can see this is in the large confidence intervals: the lines span from small to large and they all cross 0. So while most outcomes favour the treatment, there is a lot of uncertainty around the effect and none provides clear evidence. 1100
ME/CFS Science @mecfsscience.org · 17/09/20266) BioVie, however, points to results of subgroup analyses. If they restrict the comparison to participants who had a high symptom score at baseline, they did find effects favouring Bezisterim (but still with large confidence intervals). 180
ME/CFS Science @mecfsscience.org · 17/09/20267) A big question is: was this analysis planned in advance or they did go searching for a good result in the data? I couldn't find it in the protocol or trial registration but BioVie says the analysis was pre-specified in what they submitted to the FDA. 2100
