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ME/CFS Science @mecfsscience.org · 17/09/2026

1) The pharma company BioVie announced the results of the phase 2 trial of their drug Bezisterim for Long Covid. Although the primary analysis showed no significant effect, an analysis in subgroups with a great symptom burden suggested an improvement. A brief breakdown 👇

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ME/CFS Science @mecfsscience.org · 17/09/2026

2) First a bit about the drug: Bezisterim is a synthetic derivative of androstenetriol, a steroid precursor. It can cross the blood brain barrier and is believed to reduced insulin resistance and dampen inflammatory pathways.

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ME/CFS Science @mecfsscience.org · 17/09/2026

3) This was a phase 2 trial, so a preliminary and smaller study on 203 LC patients. It is meant to explore the effects of the drug, not confirm if it works or not. We also don't have the full results yet, just the press release of the biopharma company.

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