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ME/CFS Science @mecfsscience.org · 17/08/2026

1) 🇩🇰 Looks like there's a new ME/CFS trial in Denmark called 'REenergizeME'. It will test intermittent hypoxiahyperoxia treatment (IHHT) in 104 female patients selected using the international consensus criteria. It includes FUNCAP and several objective outcomes.

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ME/CFS Science @mecfsscience.org · 17/08/2026

2) The treatment consists of repeated cycles of hypoxic and hyperoxic exposure. So patients get periods with too much and too little oxygen using the HypoxBreath device, which dynamically adjusts the fraction of inspired oxygen. (Image below taken from hypox-breath.com/en/)

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ME/CFS Science @mecfsscience.org · 17/08/2026

3) The authors suspect ME/CFS pathology involves recurrent episodes of mild hypoxic injury, where the brain or muscles get too little oxygen. The treatment IHHT aims to enhance hypoxia tolerance through activation of cellular stress-response and antioxidant repair pathways.

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