ME/CFS Science @mecfsscience.org · 14/08/20264) Let's start with the cerebral blood flow, measured using arterial spin labelling (ASL). Here, the differences weren't very clear. There was a trend toward lower increases in blood flow during the second hypoxia test, but not across all regions. 1100
ME/CFS Science @mecfsscience.org · 14/08/20265) The clearest finding was increased lactate (elevated thalamic lactate-to-creatine ratio: Lac/tCr) in ME/CFS patients, but this was already the case before the challenges. In controls, these levels rose during hypoxia, whereas this was not the case for patients. 1120
ME/CFS Science @mecfsscience.org · 14/08/20266) The authors highlighted that previous ME/CFS studies found something similar. "The elevated baseline thalamic Lac/tCr is consistent with the most reproducible spectroscopic finding in ME/CFS - increased ventricular and cerebral lactate." 1140
