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ME/CFS Science @mecfsscience.org · 14/08/2026

2) The study included 26 ME/CFS patients and 27 controls. Participants were put in an MRI scanner for an hour under normal conditions, but afterwards they also did two 30-minute sessions with reduced oxygen. Using a breathing mask, oxygen saturation was lowered to ca 87%.

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ME/CFS Science @mecfsscience.org · 14/08/2026

3) The idea is that resting scans may look normal and that the problem in ME/CFS lies in how the brain responds to a controlled challenge or stressor. The results did not fully support this conclusion, though.

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ME/CFS Science @mecfsscience.org · 14/08/2026

4) Let's start with the cerebral blood flow, measured using arterial spin labelling (ASL). Here, the differences weren't very clear. There was a trend toward lower increases in blood flow during the second hypoxia test, but not across all regions.

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