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ME/CFS Science @mecfsscience.org · 06/08/2026

7) According to the authors, these results show that the fatigue of ME/CFS patients is central in origin: the brain and muscle activity associated with fatigue in controls was absent in patients. They suspect something in the brain is inhibiting this and causing early fatigue.

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ME/CFS Science @mecfsscience.org · 06/08/2026

8) Although the authors argue that "this lack of engagement is not conscious or deliberate" they mention fear of post-exertional malaise and elevated perceived exertion as potential mechanisms. These are the same authors who published the controversial effort preference theory.

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ME/CFS Science @mecfsscience.org · 06/08/2026

9) The main limitation of the study is the small sample size: only 15 ME/CFS patients and 11 were already in the intramural NIH study (so it's not an independent replication). Would be interesting to do these tests in patients with muscle disease and depression as controls.

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