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ME/CFS Science @mecfsscience.org · 13/07/2026

6) The authors think this points to a problem with cholinergic fibers and they connect this to dysautonomia and orthostatic intolerance (reported by 2/3rds of their patients). There was for example a correlation between fiber density and heart rate variability parameters.

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ME/CFS Science @mecfsscience.org · 13/07/2026

7) In the discussion the authors reflect on their finding and write: "it suggests that autonomic dysfunction in Long-COVID-19 is not merely a functional disturbance but may reflect an underlying structural lesion."

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ME/CFS Science @mecfsscience.org · 13/07/2026

8 ) This seems like an overstatement given the limitations and preliminary nature of this study (single center, only 12 patients, dyspeptic controls, no corrections for multiple comparisons). Will still be interesting to see if anyone can replicate these findings though.

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