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ME/CFS Science @mecfsscience.org · 29/06/2026

1) 🇯🇵 A Japanese group published their hypothesis of Long Covid. They suspect SARSCoV-2 causes a reactivation of another virus (HHV-6B) in the olfactory bulb where it produces a protein (SITH-1) that reduces acetylcholine levels in the brain. Let's have a closer look...

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ME/CFS Science @mecfsscience.org · 29/06/2026

2) These researchers had previously done a mouse experiment where SARS-CoV-2 spike (S1) protein in the nasal cavity caused fatigue- and depression-like symptoms and reduced acetylcholine. Symptoms were improved with the drug donepezil (an acetylcholinesterase inhibitor)

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ME/CFS Science @mecfsscience.org · 29/06/2026

3) They then tested donepezil in randomized controlled trial of 110 Long Covid patients but unfortunately it did not have any significant effect on fatigue or depression. Link here: jamanetwork.com/jour... So the authors had to adjust their hypothesis...

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